Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

• Published in: Nature reviews. Drug discovery Vol. 16; no. 10; pp. 699 - 717
• Main Authors: Cahill, Thomas J., Choudhury, Robin P., Riley, Paul R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2017; Nature Publishing Group
• Subjects: 631/154; 631/443/592/75; 631/61/490; Animals; Biomedicine; Biotechnology; Cancer Research; Cardiomyocytes; Care and treatment; Cell transplantation; Clinical Trials as Topic - methods; Development and progression; Heart attack; Heart attacks; Humans; Medical research; Medicinal Chemistry; Methods; Molecular Medicine; Myocardial Infarction - genetics; Myocardial Infarction - metabolism; Myocardial Infarction - therapy; Myocytes, Cardiac - physiology; Myocytes, Cardiac - transplantation; Patient outcomes; Pharmacology/Toxicology; Regeneration (Biology); Regeneration - physiology; review-article; Rodents; Stem Cell Transplantation - methods; Stem Cell Transplantation - trends; Translational Research, Biomedical - methods; Translational Research, Biomedical - trends

Key Points Endogenous regeneration seen in animal models provides a template for optimal repair of the human heart following myocardial infarction. In the regenerating heart, new cardiomyocytes are produced by proliferation of the existing cardiomyocyte pool. Understanding and targeting the intrinsi...