Potential role of oxidative stress-induced apoptosis in mediating chromosomal rearrangements in nasopharyngeal carcinoma

• Published in: Cell & bioscience Vol. 6; no. 35; p. 35
• Main Authors: Tan, Sang-Nee, Sim, Sai-Peng, Khoo, Alan S B
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.05.2016; BioMed Central
• Subjects: Analysis; Apoptosis; Cancer; Carcinoma; Genes; Genetic aspects; Leukemia; Oxidative stress; NPC; Oxidative stress; AF9 gene; H2O2; CAD; Apoptosis

Genetic aberrations have been identified in nasopharyngeal carcinoma (NPC), however, the underlying mechanism remains elusive. There are increasing evidences that the apoptotic nuclease caspase-activated deoxyribonuclease (CAD) is one of the players leading to translocation in leukemia. Oxidative st...