Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids

• Published in: Frontiers in endocrinology (Lausanne) Vol. 11; p. 617
• Main Authors: Ye, Zhenhong, Wang, Siyu, Zhang, Chunmei, Zhao, Yue
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.09.2020
• Subjects: Amino Acids, Branched-Chain - metabolism; branched-amino acids; Endocrinology; energy metabolism; Energy Metabolism - physiology; fatty acids; Fatty Acids - metabolism; Humans; inflammation; Inflammation - metabolism; insulin resistance; Insulin Resistance - physiology; Lipid Metabolism - physiology; mitochondrial biogenesis; Organelle Biogenesis; Oxidative Phosphorylation; Signal Transduction - physiology; branched-amino acids; fatty acids; inflammation; insulin resistance; mitochondrial biogenesis; energy metabolism

As important metabolic substrates, branched-chain amino acids (BCAAs) and fatty acids (FAs) participate in many significant physiological processes, such as mitochondrial biogenesis, energy metabolism, and inflammation, along with intermediate metabolites generated in their catabolism. The increased...