Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

• Published in: Frontiers in pharmacology Vol. 11; p. 75
• Main Authors: Bush, Nigel, Healey, Andrew, Shah, Anant, Box, Gary, Kirkin, Vladimir, Eccles, Sue, Sontum, Per Christian, Kotopoulis, Spiros, Kvåle, Svein, van Wamel, Annemieke, Davies, Catharina de Lange, Bamber, Jeffrey
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.02.2020
• Subjects: acoustic cluster therapy; breast cancer; doxorubicin; drug delivery; microbubbles; Pharmacology; ultrasound; acoustic cluster therapy; breast cancer; microbubbles; doxorubicin; drug delivery; ultrasound

Acoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug ( , a chemotherapeutic) and local ultrasound (US) insonation of the targeted pathological tissue ( , the tumor). PS101 is confined...