Next-generation sequencing in familial breast cancer patients from Lebanon

• Published in: BMC medical genomics Vol. 10; no. 1; p. 8
• Main Authors: Jalkh, Nadine, Chouery, Eliane, Haidar, Zahraa, Khater, Christina, Atallah, David, Ali, Hamad, Marafie, Makia J, Al-Mulla, Mohamed R, Al-Mulla, Fahd, Megarbane, Andre
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.02.2017; BioMed Central
• Subjects: Adult; Aged; BRCA1 Protein - genetics; BRCA2 Protein - genetics; Breast cancer; Breast Neoplasms - genetics; Cancer; Diagnosis; DNA Mutational Analysis; DNA sequencing; Female; Genetic aspects; Genetic Predisposition to Disease - genetics; Health aspects; High-Throughput Nucleotide Sequencing; Humans; Lebanon; Methods; Middle Aged; Mutation; Nucleotide sequencing; Lebanon; Exome; Lebanon; BRCA; Next-generation sequencing; Familial; Breast cancer; Mutation; Germline

Familial breast cancer (BC) represents 5 to 10% of all BC cases. Mutations in two high susceptibility BRCA1 and BRCA2 genes explain 16-40% of familial BC, while other high, moderate and low susceptibility genes explain up to 20% more of BC families. The Lebanese reported prevalence of BRCA1 and BRCA...