Update on the use of immunoglobulin in human disease: A review of evidence

• Published in: Journal of allergy and clinical immunology Vol. 139; no. 3; pp. S1 - S46
• Main Authors: Perez, Elena E., Orange, Jordan S., Bonilla, Francisco, Chinen, Javier, Chinn, Ivan K., Dorsey, Morna, El-Gamal, Yehia, Harville, Terry O., Hossny, Elham, Mazer, Bruce, Nelson, Robert, Secord, Elizabeth, Jordan, Stanley C., Stiehm, E. Richard, Vo, Ashley A., Ballow, Mark
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2017
• Subjects: adverse events; Allergy and Immunology; Animals; autoimmunity; Evidence-Based Medicine; Humans; IGIV; Immune globulin; immune modulating; Immunity, Humoral; immunoglobulin; Immunoglobulins - therapeutic use; Immunoglobulins, Intravenous - therapeutic use; Immunologic Deficiency Syndromes - immunology; Immunologic Deficiency Syndromes - therapy; Immunomodulation; Injections, Subcutaneous; IVIG; Practice Guidelines as Topic; primary immunodeficiency; SCIG; transfusion; immunomodulation; CLL; FDA; RCT; APS; ITP; SCIG; WAS; transfusion; GVHD; XLA; SCID; SC; immune modulating; CVID; DSA; THI; Immune globulin; primary immunodeficiency; GBS; KD; MG; BMI; MM; SCORAD; AD; JIA; immunoglobulin; MS; IVIG; IGIV; ISR; VOD; adverse events; CIDP; IV; MMN; RA; AT; autoimmunity; RSV; PE; PI; LEMS; PAN; HAART; Transient hypogammaglobulinemia; Multiple sclerosis; Common variable immunodeficiency; Donor-specific HLA antigen; Juvenile idiopathic arthritis; Veno-occlusive disease; Body mass index; Multifocal motor neuropathy; Atopic dermatitis; US Food and Drug Administration; Wiskott-Aldrich syndrome; Subcutaneous; Severity scoring of Alzheimer disease; Randomized controlled trial; Guillain-Barré syndrome; Lambert-Eaton myasthenic syndrome; Rheumatoid arthritis; Ataxia telangiectasia; Highly active antiretroviral treatment; Anti–phospholipid antibody syndrome; Subcutaneous immunoglobulin; Severe combined immunodeficiency; Polyarteritis nodosa; Multiple myeloma; X-linked agammaglobulinemia; Plasma exchange; Kawasaki disease; Myasthenia gravis; Infusion site reaction; Graft-versus-host disease; Intravenous; Intravenous immunoglobulin; Chronic lymphocytic leukemia; Respiratory syncytial virus; Immune thrombocytopenic purpura; Chronic inflammatory demyelinating polyneuropathy

Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in hum...