Stem cell factor programs the mast cell activation phenotype

• Published in: The Journal of immunology (1950) Vol. 188; no. 11; pp. 5428 - 5437
• Main Authors: Ito, Tomonobu, Smrž, Daniel, Jung, Mi-Yeon, Bandara, Geethani, Desai, Avanti, Smržová, Šárka, Kuehn, Hye Sun, Beaven, Michael A, Metcalfe, Dean D, Gilfillan, Alasdair M
• Format: Journal Article
• Language: English
• Published: United States 01.06.2012
• Subjects: Animals; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Bone Marrow Cells - metabolism; Cell Degranulation - immunology; Cell Proliferation; Cells, Cultured; Coculture Techniques; Homeostasis - immunology; Hypersensitivity - immunology; Hypersensitivity - metabolism; Hypersensitivity - pathology; Immunophenotyping; Mast Cells - cytology; Mast Cells - immunology; Mast Cells - metabolism; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Stem Cell Factor - physiology

Mast cells, activated by Ag via FcεRI, release an array of proinflammatory mediators that contribute to allergic disorders, such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation, and survival, and under acute conditions, it enhan...