5′-Long Terminal Repeat-Selective CpG Methylation of Latent Human T-Cell Leukemia Virus Type 1 Provirus In Vitro and In Vivo

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Published inJournal of Virology Vol. 76; no. 18; pp. 9389 - 9397
Main Authors Koiwa, Tsukasa, Hamano-Usami, Akiko, Ishida, Takaomi, Okayama, Akihiko, Yamaguchi, Kazunari, Kamihira, Shimeru, Watanabe, Toshiki
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.09.2002
Subjects
Base Sequence
Carrier State - virology
Cell Line
CpG Islands - physiology
DNA Methylation
DNA, Viral - metabolism
Gene Expression Regulation, Viral
HTLV-I Infections - virology
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - metabolism
Humans
Leukocytes, Mononuclear - virology
Molecular Sequence Data
Pathogenesis and Immunity
Proviruses - metabolism
Proviruses - physiology
Sequence Analysis, DNA
Terminal Repeat Sequences - physiology
Virus Latency
Online AccessGet full text

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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList CpG methylation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat (LTR) has been implicated in proviral latency, but there is presently little information available regarding the pattern of LTR methylation and its effect on viral gene expression. To gain insight into the mechanisms of HTLV-1 latency, we have studied methylation of individual CpG sites in the U3-R region of the integrated proviral LTR by using bisulfite genomic sequencing methods. Surprisingly, our results reveal selective hypermethylation of the 5' LTR and accompanying hypomethylation of the 3' LTR in both latently infected cell lines and adult T-cell leukemia (ATL) cells having a complete provirus. Moreover, we observed a lack of CpG methylation in the LTRs of 5'-defective proviruses recovered from ATL samples, which is consistent with the selective hypomethylation of the 3' LTR. Thus, the integrated HTLV-1 provirus in these carriers appears to be hypermethylated in the 5' LTR and hypomethylated in the 3' LTR. These results, together with the observation that proviral gene expression is reactivated by 5-azacytidine in latently infected cell lines, indicate that selective hypermethylation of the HTLV-1 5' LTR is common both in vivo and in vitro. Thus, hypermethylation of the 5' LTR appears to be an important mechanism by which HTLV-1 gene expression is repressed during viral latency.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author Akihiko Okayama
Takaomi Ishida
Toshiki Watanabe
Shimeru Kamihira
Tsukasa Koiwa
Kazunari Yamaguchi
Akiko Hamano-Usami
AuthorAffiliation Division of Pathology, Department of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, 1 Department of Internal Medicine, Miyazaki Medical College, Miyazaki 889-1601, 2 Blood Transfusion Service, Kumamoto University, Kumamoto 860-8556, 3 Department of Laboratory Medicine, Nagasaki University, Nagasaki 852-8523, Japan 4
AuthorAffiliation_xml – name: Division of Pathology, Department of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, 1 Department of Internal Medicine, Miyazaki Medical College, Miyazaki 889-1601, 2 Blood Transfusion Service, Kumamoto University, Kumamoto 860-8556, 3 Department of Laboratory Medicine, Nagasaki University, Nagasaki 852-8523, Japan 4
Author_xml – sequence: 1
  givenname: Tsukasa
  surname: Koiwa
  fullname: Koiwa, Tsukasa
  organization: Division of Pathology, Department of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
– sequence: 2
  givenname: Akiko
  surname: Hamano-Usami
  fullname: Hamano-Usami, Akiko
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  surname: Ishida
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  surname: Okayama
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  surname: Kamihira
  fullname: Kamihira, Shimeru
– sequence: 7
  givenname: Toshiki
  surname: Watanabe
  fullname: Watanabe, Toshiki
BackLink https://www.ncbi.nlm.nih.gov/pubmed/12186921$$D View this record in MEDLINE/PubMed
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Corresponding author. Mailing address: Division of Pathology, Department of Cancer Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Phone: 81-3-5449-5298. Fax: 81-3-5449-5418. E-mail: tnabe@ims.u-tokyo.ac.jp.
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Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
CpG methylation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat (LTR) has been implicated in proviral latency, but there is presently...
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StartPage 9389
SubjectTerms Base Sequence
Carrier State - virology
Cell Line
CpG Islands - physiology
DNA Methylation
DNA, Viral - metabolism
Gene Expression Regulation, Viral
HTLV-I Infections - virology
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - metabolism
Humans
Leukocytes, Mononuclear - virology
Molecular Sequence Data
Pathogenesis and Immunity
Proviruses - metabolism
Proviruses - physiology
Sequence Analysis, DNA
Terminal Repeat Sequences - physiology
Virus Latency
Title 5′-Long Terminal Repeat-Selective CpG Methylation of Latent Human T-Cell Leukemia Virus Type 1 Provirus In Vitro and In Vivo
URI http://jvi.asm.org/content/76/18/9389.abstract
https://www.ncbi.nlm.nih.gov/pubmed/12186921
https://search.proquest.com/docview/18484724
https://search.proquest.com/docview/72004180
https://pubmed.ncbi.nlm.nih.gov/PMC136445
Volume 76
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