Plasma concentrations of ascorbic acid in a cross section of the German population

Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant–patient seminar on nutrition and food intolerances, patients were asked to participat...

Full description

Saved in:
Bibliographic Details
Published inJournal of international medical research Vol. 46; no. 1; pp. 168 - 174
Main Authors Hagel, Alexander F., Albrecht, Heinz, Dauth, Wolfgang, Hagel, Wolfgang, Vitali, Francesco, Ganzleben, Ingo, Schultis, Hans W., Konturek, Peter C., Stein, Jürgen, Neurath, Markus F., Raithel, Martin
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2018
Sage Publications Ltd
SAGE Publishing
Subjects
Adult
Age Factors
Aged
Aged, 80 and over
Ascorbic Acid - blood
Ascorbic Acid Deficiency - blood
Ascorbic Acid Deficiency - diagnosis
Ascorbic Acid Deficiency - epidemiology
Body Mass Index
Cross-Sectional Studies
Female
Germany - epidemiology
Humans
Incidence
Male
Middle Aged
Questionnaires
Research Report
Sex Factors
Surveys and Questionnaires
Vitamin C
Vitamin E
ascorbic acid
deficiency
body mass index
Vitamin C
scurvy
Online AccessGet full text

Cover

Abstract Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant–patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50–17.40; reference range, 5–15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.
AbstractList Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant-patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50-17.40; reference range, 5-15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.
Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant-patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50-17.40; reference range, 5-15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant-patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50-17.40; reference range, 5-15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.
ObjectivesVitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population.MethodsAs part of a consultant–patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography.ResultsOf approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50–17.40; reference range, 5–15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%).ConclusionsPotential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.
Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in the German population. Methods As part of a consultant–patient seminar on nutrition and food intolerances, patients were asked to participate in this study on a voluntary basis. Blood samples were taken for analysis of serum vitamin C concentrations, and all patients were asked to complete a questionnaire. The vitamin C concentration was determined by high-performance liquid chromatography. Results Of approximately 300 patients attending the seminar, 188 (62.6%) consented to vitamin C blood sample analysis and 178 (59.3%) answered the questionnaire. The mean vitamin C concentration was 7.98 mg/L (range, 0.50–17.40; reference range, 5–15 mg/L). A low plasma level with vitamin C insufficiency (<5 mg/L) was found in 31 patients (17.4%), and a potential scorbutogenic deficiency (<1.5 mg/L) was found in 6 (3.3%). Conclusions Potential vitamin C insufficiency and deficiency is common. It is therefore possible, even in modern developed populations, that certain individuals may require a higher intake of vitamin C.
Author Hagel, Wolfgang
Konturek, Peter C.
Hagel, Alexander F.
Vitali, Francesco
Schultis, Hans W.
Neurath, Markus F.
Albrecht, Heinz
Stein, Jürgen
Ganzleben, Ingo
Dauth, Wolfgang
Raithel, Martin
AuthorAffiliation 2 Institute of Employment Research, Nuremberg, Germany
5 Thuringia Clinics, Gastroenterology, Saalfeld, Germany
4 Synlab, Weiden, Germany
3 Department of Medicine 6, Paracelsus Medical University, Nuremberg, Germany
1 Department of Medicine 1, University of Erlangen – Nuremberg, Germany
6 Department of Nutritional Medicine, Sachsenhausen University Hospital, Frankfurt/Main, Germany
AuthorAffiliation_xml – name: 5 Thuringia Clinics, Gastroenterology, Saalfeld, Germany
– name: 3 Department of Medicine 6, Paracelsus Medical University, Nuremberg, Germany
– name: 6 Department of Nutritional Medicine, Sachsenhausen University Hospital, Frankfurt/Main, Germany
– name: 4 Synlab, Weiden, Germany
– name: 2 Institute of Employment Research, Nuremberg, Germany
– name: 1 Department of Medicine 1, University of Erlangen – Nuremberg, Germany
Author_xml – sequence: 1
  givenname: Alexander F.
  surname: Hagel
  fullname: Hagel, Alexander F.
  email: alexander.hagel@uk-erlangen.de
– sequence: 2
  givenname: Heinz
  surname: Albrecht
  fullname: Albrecht, Heinz
– sequence: 3
  givenname: Wolfgang
  surname: Dauth
  fullname: Dauth, Wolfgang
– sequence: 4
  givenname: Wolfgang
  surname: Hagel
  fullname: Hagel, Wolfgang
  email: alexander.hagel@uk-erlangen.de
– sequence: 5
  givenname: Francesco
  surname: Vitali
  fullname: Vitali, Francesco
– sequence: 6
  givenname: Ingo
  surname: Ganzleben
  fullname: Ganzleben, Ingo
– sequence: 7
  givenname: Hans W.
  surname: Schultis
  fullname: Schultis, Hans W.
– sequence: 8
  givenname: Peter C.
  surname: Konturek
  fullname: Konturek, Peter C.
– sequence: 9
  givenname: Jürgen
  surname: Stein
  fullname: Stein, Jürgen
– sequence: 10
  givenname: Markus F.
  surname: Neurath
  fullname: Neurath, Markus F.
– sequence: 11
  givenname: Martin
  surname: Raithel
  fullname: Raithel, Martin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28760081$$D View this record in MEDLINE/PubMed
BookMark eNp9ks1rFTEUxYNU7Gt170oCbroZTTL5mo0gxdZCQRFdh3zNax4zyTOZEfzvzbyp1T7QVULu7xxO7r1n4CSm6AF4idEbjIV4i1qEEEes3jFtpXgCNpiKtiH1_QRslnKz1E_BWSk7hCjhjDwDp0QKjpDEG_Dl86DLqKFN0fo4ZT2FFAtMPdTFpmyChdoGB0OEFcqpFFi8XaCFme48vPZ51BHu034eDurn4Gmvh-Jf3J_n4NvVh6-XH5vbT9c3l-9vG8uInBpjRI-IlL6zjhlkhZS8s6b1xhnpqPC965ljsjNYW9Yh4a3hPeaUWEMRN-05uFl9XdI7tc9h1PmnSjqow0PKW6XzFOzgVWs7TD2i3DFGOys70mJNe2cNwkYaX73erV772Yzera0YHpk-rsRwp7bph-IIY9KxanBxb5DT99mXSY2hWD8MOvo0F4U7woioYyIVfX2E7tKcY22VqrHaymAmK_Xq70QPUX6PrgJoBQ5Tyb5_QDBSy3ao4-2oEn4ksWE6zKz-KQz_EzarsOit_xP3n_wvSojJtA
CitedBy_id crossref_primary_10_1016_j_cherd_2024_04_048
crossref_primary_10_1016_j_cca_2021_03_009
crossref_primary_10_1111_ans_18845
crossref_primary_10_1016_j_sbsr_2020_100348
crossref_primary_10_33224_rrch_2024_69_10_12_10
crossref_primary_10_1016_j_electacta_2023_142238
crossref_primary_10_1109_TNANO_2022_3218922
crossref_primary_10_1089_ars_2019_7912
crossref_primary_10_5694_mja2_52132
crossref_primary_10_1080_08839514_2022_2042924
crossref_primary_10_1088_1361_6501_ac1235
crossref_primary_10_3390_nu14112189
crossref_primary_10_1016_j_saa_2023_122425
crossref_primary_10_1016_j_jinorgbio_2022_112024
crossref_primary_10_3390_nu13030791
crossref_primary_10_1021_acssensors_2c02780
crossref_primary_10_1007_s00604_022_05322_5
crossref_primary_10_36290_ped_2021_018
crossref_primary_10_1055_a_1593_8153
crossref_primary_10_1016_j_ejps_2024_106721
crossref_primary_10_1093_jbcr_iraa041
crossref_primary_10_1109_TIM_2022_3223074
crossref_primary_10_1115_1_4041901
crossref_primary_10_3390_bios13121032
crossref_primary_10_1016_j_ccr_2022_214567
crossref_primary_10_1063_5_0194200
crossref_primary_10_3389_fchem_2021_633547
crossref_primary_10_36290_lek_2022_004
crossref_primary_10_1016_j_snb_2021_130722
crossref_primary_10_1016_j_jtice_2021_06_018
crossref_primary_10_1021_acsanm_0c02067
crossref_primary_10_3390_bios13060588
crossref_primary_10_1007_s42114_022_00614_z
crossref_primary_10_1016_j_snb_2022_132647
crossref_primary_10_14336_AD_2020_0918
crossref_primary_10_1016_j_apsusc_2023_157386
crossref_primary_10_1039_D4DT01534G
crossref_primary_10_1016_j_talanta_2024_126769
crossref_primary_10_1007_s00053_024_00796_8
crossref_primary_10_7759_cureus_13158
crossref_primary_10_1007_s00394_024_03426_7
crossref_primary_10_1002_admt_202100096
crossref_primary_10_3390_nu15071645
crossref_primary_10_1134_S1070363223110300
crossref_primary_10_1149_1945_7111_ad541c
crossref_primary_10_1007_s00266_020_01865_1
crossref_primary_10_1016_j_matpr_2022_11_213
crossref_primary_10_1021_acs_analchem_2c00017
crossref_primary_10_1016_j_ab_2024_115574
crossref_primary_10_3390_biomedicines10092124
crossref_primary_10_3390_ijms25137276
crossref_primary_10_12974_2311_8687_2018_06_3
crossref_primary_10_1016_j_exger_2019_110782
crossref_primary_10_3389_fmed_2022_907067
crossref_primary_10_1542_pir_2021_005222
crossref_primary_10_3390_ijms21176332
crossref_primary_10_1002_stem_3259
crossref_primary_10_1016_j_ctcp_2023_101733
Cites_doi 10.1024/0300-9831/a000188
10.1024/0300-9831/a000179
10.1007/s00210-013-0880-1
10.1007/s001250050927
10.1007/s003910050072
10.1024/0300-9831/a000070
10.1016/j.cca.2006.08.028
10.3945/ajcn.2008.27016
10.1093/aje/kwp156
10.1006/abio.2000.4592
10.1093/jn/110.4.662
10.1055/s-0032-1325487
10.1016/j.clinbiochem.2005.01.018
10.1024/0300-9831/a000202
ContentType Journal Article
Copyright The Author(s) 2017
The Author(s) 2017. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2017 2017 SAGE Publications
Copyright_xml – notice: The Author(s) 2017
– notice: The Author(s) 2017. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2017 2017 SAGE Publications
DBID AFRWT
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1177/0300060517714387
DatabaseName Sage Journals GOLD Open Access 2024
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE

MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: AFRWT
  name: Sage Journals GOLD Open Access 2024
  url: http://journals.sagepub.com/
  sourceTypes: Publisher
– sequence: 5
  dbid: 7X7
  name: Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1473-2300
EndPage 174
ExternalDocumentID oai_doaj_org_article_3c914e046d5549c89231a4fdcb01b8be
PMC6011295
28760081
10_1177_0300060517714387
10.1177_0300060517714387
Genre Journal Article
GroupedDBID ---
.55
.GJ
01A
0R~
29K
2WC
44B
53G
54M
5GY
5RE
5VS
7X7
8FI
8FJ
AABQO
AACKU
AAFWJ
AAGGD
AAJIQ
AAJOX
AAJPV
AAJQC
AANSI
AAPEO
AAQQG
AAQXH
AASGM
AAXOT
AAYTG
AAZBJ
ABAFQ
ABAWP
ABDWY
ABHKI
ABJNI
ABNCE
ABPGX
ABQKF
ABQXT
ABUWG
ABVFX
ABXGC
ABYTW
ACARO
ACFMA
ACFYK
ACGBL
ACGFS
ACLHI
ACROE
ADBBV
ADEIA
ADMPF
ADOGD
ADQSQ
ADTBJ
ADUKL
AECVZ
AEFTW
AENEX
AERKM
AEUHG
AEWDL
AEXFG
AFCOW
AFKBI
AFKRA
AFKRG
AFPKN
AFRWT
AIGRN
AJABX
AJEFB
AJMMQ
AJSCY
AJUZI
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AUTPY
AYAKG
BAWUL
BCNDV
BDDNI
BENPR
BPHCQ
BSEHC
BVXVI
CBRKF
CCPQU
CORYS
CQQTX
CUTAK
D-I
DC.
DF.
DIK
E3Z
EBD
EBS
EF0
EJD
EMOBN
F5P
FYUFA
GROUPED_DOAJ
GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION
H13
HMCUK
HYE
J8X
K.F
KQ8
L7B
MK0
O9-
P2P
PHGZM
PHGZT
PIMPY
PQQKQ
Q1R
ROL
RPM
S01
SAUOL
SCDPB
SCNPE
SFC
SV3
TR2
TUS
UKHRP
X7M
ZE2
ZGI
AAEJI
AAYXX
ACHEB
CITATION
OVT
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
8FK
AZQEC
DWQXO
K9.
PKEHL
PQEST
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c528t-bb7f0288e9cd5b0c78869cb3ebdb8d47efdf5d589b1ac5907ecb6f1642cb406b3
IEDL.DBID 7X7
ISSN 0300-0605
1473-2300
IngestDate Wed Aug 27 01:27:32 EDT 2025
Thu Aug 21 18:25:19 EDT 2025
Thu Jul 10 17:33:23 EDT 2025
Sun Jul 13 05:34:30 EDT 2025
Mon Jul 21 06:05:42 EDT 2025
Thu Apr 24 22:55:34 EDT 2025
Wed Aug 20 07:40:39 EDT 2025
Tue Jun 17 22:28:25 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords ascorbic acid
deficiency
body mass index
Vitamin C
scurvy
Language English
License This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c528t-bb7f0288e9cd5b0c78869cb3ebdb8d47efdf5d589b1ac5907ecb6f1642cb406b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.proquest.com/docview/2313771158?pq-origsite=%requestingapplication%
PMID 28760081
PQID 2313771158
PQPubID 4451107
PageCount 7
ParticipantIDs doaj_primary_oai_doaj_org_article_3c914e046d5549c89231a4fdcb01b8be
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6011295
proquest_miscellaneous_1925277712
proquest_journals_2313771158
pubmed_primary_28760081
crossref_primary_10_1177_0300060517714387
crossref_citationtrail_10_1177_0300060517714387
sage_journals_10_1177_0300060517714387
PublicationCentury 2000
PublicationDate 2018-01-01
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – month: 01
  year: 2018
  text: 2018-01-01
  day: 01
PublicationDecade 2010
PublicationPlace London, England
PublicationPlace_xml – name: London, England
– name: England
– name: London
– name: Sage UK: London, England
PublicationTitle Journal of international medical research
PublicationTitleAlternate J Int Med Res
PublicationYear 2018
Publisher SAGE Publications
Sage Publications Ltd
SAGE Publishing
Publisher_xml – name: SAGE Publications
– name: Sage Publications Ltd
– name: SAGE Publishing
References Northrop-Clewes, Thurnham 2007; 377
Clemetson 1980; 110
Ahmed, Haboubi 2010; 5
Choi, Song, Paek 2013; 83
Lykkesfeldt 2000; 282
Weidenhiller, Layritz, Hagel 2012; 50
Gariballa 2014; 84
Ng, Ngkeekwong, Quinn 1998; 41
Willers, Heinemann, Bitterlich 2014; 84
Schleicher, Carroll, Ford 2009; 90
Douglas, Hemila, D'Souza 2004
Wilson 1975; 25
Cahill, Corey, El-Sohemy 2009; 170
Breidenassel, Valtueña, González-Gross 2011; 81
Gritschneder, Herbert, Lührmann 1998; 31
Emadi-Konjin, Verjee, Levin 2005; 38
Hagel, Layritz, Hagel 2013; 386
bibr5-0300060517714387
bibr16-0300060517714387
bibr11-0300060517714387
bibr14-0300060517714387
bibr7-0300060517714387
bibr13-0300060517714387
bibr8-0300060517714387
Wilson CW (bibr15-0300060517714387) 1975; 25
Douglas RM (bibr12-0300060517714387) 2004
bibr3-0300060517714387
Ahmed T (bibr9-0300060517714387) 2010; 5
bibr1-0300060517714387
bibr10-0300060517714387
bibr17-0300060517714387
bibr4-0300060517714387
bibr6-0300060517714387
bibr18-0300060517714387
bibr2-0300060517714387
References_xml – volume: 31
  start-page: 448
  year: 1998
  end-page: 453
  article-title: Nutritional status of participants in the Giessen Senior Long-Term Study with respect to antioxidant vitamins and selenium
  publication-title: Z Gerontol Geriat
– volume: 84
  start-page: 12
  year: 2014
  end-page: 17
  article-title: Poor vitamin C status is associated with increased depression symptoms following acute illness in older people
  publication-title: Int J Vitam Nutr Res
– volume: 25
  start-page: 354
  year: 1975
  end-page: 376
  article-title: Clinical pharmacological aspects of ascorbic acid
  publication-title: Ann NY Acad Sci
– volume: 38
  start-page: 450
  year: 2005
  end-page: 456
  article-title: Measurement of intracellular vitamin C levels in human lymphocytes by reverse phase high performance liquid chromatography (HPLC)
  publication-title: Clin Biochem
– volume: 41
  start-page: 435
  year: 1998
  end-page: 442
  article-title: Uptake mechanisms for ascorbate and dehydroascorbate in lymphoblasts from diabetic nephropathy and hypertensive patients
  publication-title: Diabetologia
– volume: 84
  start-page: 152
  year: 2014
  end-page: 162
  article-title: Vitamin Intake from Food Supplements in a German Cohort - Is there a Risk of Excessive Intake?
  publication-title: Int J Vitam Nutr Res
– start-page: CD000980
  issue: 4
  year: 2004
  end-page: CD000980
  article-title: Vitamin C for preventing and treating the common cold
  publication-title: Cochrane Database Syst Rev
– volume: 170
  start-page: 464
  year: 2009
  end-page: 471
  article-title: Vitamin C deficiency in a population of young Canadian adults
  publication-title: Am J Epidemiol
– volume: 110
  start-page: 662
  year: 1980
  end-page: 668
  article-title: Histamine and ascorbic acid in human blood
  publication-title: J Nutr
– volume: 377
  start-page: 14
  year: 2007
  end-page: 38
  article-title: Monitoring micronutrients in cigarette smokers
  publication-title: Clin Chim Acta
– volume: 81
  start-page: 245
  year: 2011
  end-page: 255
  article-title: Antioxidant vitamin status (A, E, C, and beta-carotene) in European adolescents - the HELENA Study
  publication-title: Int J Vitam Nutr Res
– volume: 5
  start-page: 207
  year: 2010
  end-page: 216
  article-title: Assessment and management of nutrition in older people and its importance to health
  publication-title: Clin Interv Aging
– volume: 50
  start-page: 1302
  year: 2012
  end-page: 1309
  article-title: Histaminintoleranz-Syndrom (HIS): Vielfalt der Mechanismen von physiologischer, pathophysiologischer und toxischer Wirkung und deren Unterscheidung
  publication-title: Z Gastroenterol
– volume: 282
  start-page: 89
  year: 2000
  end-page: 93
  article-title: Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl] phosphine hydrochloride
  publication-title: Anal Biochem
– volume: 90
  start-page: 1252
  year: 2009
  end-page: 1263
  article-title: Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)
  publication-title: Am J Clin Nutr
– volume: 83
  start-page: 377
  year: 2013
  end-page: 384
  article-title: Gender differences in the relationship between vitamin C and abdominal obesity
  publication-title: Int J Vitam Nutr Res
– volume: 386
  start-page: 789
  year: 2013
  end-page: 793
  article-title: Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
– ident: bibr10-0300060517714387
  doi: 10.1024/0300-9831/a000188
– ident: bibr6-0300060517714387
  doi: 10.1024/0300-9831/a000179
– ident: bibr11-0300060517714387
  doi: 10.1007/s00210-013-0880-1
– start-page: CD000980
  issue: 4
  year: 2004
  ident: bibr12-0300060517714387
  publication-title: Cochrane Database Syst Rev
– ident: bibr4-0300060517714387
– ident: bibr17-0300060517714387
  doi: 10.1007/s001250050927
– ident: bibr3-0300060517714387
  doi: 10.1007/s003910050072
– ident: bibr8-0300060517714387
  doi: 10.1024/0300-9831/a000070
– ident: bibr14-0300060517714387
  doi: 10.1016/j.cca.2006.08.028
– volume: 25
  start-page: 354
  year: 1975
  ident: bibr15-0300060517714387
  publication-title: Ann NY Acad Sci
– ident: bibr1-0300060517714387
  doi: 10.3945/ajcn.2008.27016
– ident: bibr2-0300060517714387
  doi: 10.1093/aje/kwp156
– volume: 5
  start-page: 207
  year: 2010
  ident: bibr9-0300060517714387
  publication-title: Clin Interv Aging
– ident: bibr16-0300060517714387
  doi: 10.1006/abio.2000.4592
– ident: bibr5-0300060517714387
  doi: 10.1093/jn/110.4.662
– ident: bibr13-0300060517714387
  doi: 10.1055/s-0032-1325487
– ident: bibr18-0300060517714387
  doi: 10.1016/j.clinbiochem.2005.01.018
– ident: bibr7-0300060517714387
  doi: 10.1024/0300-9831/a000202
SSID ssj0042652
Score 2.3973298
Snippet Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in...
Objectives Vitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in...
ObjectivesVitamin C deficiency is considered extremely rare in modern industrialized countries. This study was performed to assess vitamin C concentrations in...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
sage
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 168
SubjectTerms Adult
Age Factors
Aged
Aged, 80 and over
Ascorbic Acid - blood
Ascorbic Acid Deficiency - blood
Ascorbic Acid Deficiency - diagnosis
Ascorbic Acid Deficiency - epidemiology
Body Mass Index
Cross-Sectional Studies
Female
Germany - epidemiology
Humans
Incidence
Male
Middle Aged
Questionnaires
Research Report
Sex Factors
Surveys and Questionnaires
Vitamin C
Vitamin E
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEB_knnwRv62eEkEWhCu7bZM2fVTxPARlkTu4t5KZpLig2eO693D_vTNtt3vr54tvJZ22QzLJ_KaZ_AbglfZExpsidbotUy27h3UWKPXatbUkN9V9mc5Pn8uTM_3x3JzfKPUlOWEDPfDQcfOC6kwHjuI8O76arAASfq8nXGRoMcjqyz5vG0wNazC7HTPuH0hZlYXZbVDOpU2a-FpKf1d7Dqnn7f8d2Pw1Z_JG4lfvi47vwp0RRKo3g_L34FaI92G2HFior4_U6e5QVXekZmq546e-fgBfloyYvztFcmIxjrS5nVq3ynUci-KKlKOVV6uoWEiUVl2fsBVFhgGj-iDLeVQXU_Gvh3B2_P703Uk6llZIyeR2kyJWLSMLG2ryBhfEgXBZExYBPVqvq9D6lofQ1pg5MhxAB8Ky5dAqJ2QIgMUjOIjrGJ6A4idKvfDksHC6cLY2DHkwLwk5VLF5kcB8278NjbzjUv7iW5NtqcZ_GpEEXk9PXAycG3-RfStDNskJW3bfwDbUjDbU_MuGEjjcDngzTuGuYZmCP5IZm8DL6TZPPtlRcTGsr7qG4bHJK5bKE3g82MekCYeipQCuBKo9y9lTdf9OXH3tCb45SGYYZhKYiY3tVPpTJzz9H53wDG4zGLTD76VDONhcXoXnDLg2-KKfWz8AfLcjDg
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Sage Journals GOLD Open Access 2024
  dbid: AFRWT
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lj9MwEB4t3QsXxJvAgoyEKiFtaB524pzQgigrJFC16oq9RX4FKlF31bSH_ntm8iplAXGLnIkyscfxN57xNwCvuDVGWJGGildZyCl6WMTOhJarqqDkpqIp0_n5S3Z-yT9diasj8P1ZmK4H6zeUVoUaNT9rmt20Gz3pgowTtEwiEhF4TeW787fbzbJsd7v7ohrUQuHp7ZIi24byIXdhf7rtFhwneSaSERyfTS--zvt_Ny5Xoos7UDmWSOwDmzfeebCQNXz_fwKpN3Mtf0kYa9aw6V2404FPdtZayz04cv4-jGcte_XulM33h7HqUzZmsz2v9e4BXMwQaS8VM3TS0Xd0uzVbVUzhl6_1wjBlFpYtPEMhUprVTaKXJxkEmuwjLQOeXQ9Fwx7C5fTD_P152JVkCI1I5CbUOq8QkUhXGCt0ZNCBzgqjU6etlpbnrrIVDr0sdKyMQMfbGZ1V6JIlRiN00OkjGPmVd0-A4RMZj6xROlU8VbIQCJV0khmNLo5M0gAmff-WpuMrp7IZP8q4pyj_bUQCeD08cd1ydfxD9h0N2SBHLNtNw2r9rewmbZmaIuYu4plF0FUYSWAYbdoaHcVaahfAST_gZW-4Jcqk-JJYyABeDrdx0lIkRnm32tYlwmqR5CiVBPC4tY9BE3RhMwJqAeQHlnOg6uEdv_jeEIOjc43wTQQwJhvbq_S3Tnj6v4LP4DYCRdluPZ3AaLPeuucIxjb6RTeDfgIwHy2c
  priority: 102
  providerName: SAGE Publications
Title Plasma concentrations of ascorbic acid in a cross section of the German population
URI https://journals.sagepub.com/doi/full/10.1177/0300060517714387
https://www.ncbi.nlm.nih.gov/pubmed/28760081
https://www.proquest.com/docview/2313771158
https://www.proquest.com/docview/1925277712
https://pubmed.ncbi.nlm.nih.gov/PMC6011295
https://doaj.org/article/3c914e046d5549c89231a4fdcb01b8be
Volume 46
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9tAEB7a5NJLSd9qU7OFYihEWK-VVqeSFLuh0GCMQ30T-1JqaCUncg75952R1lLdRy6WWY1g0MzufrMz-gbgfWK05obHvkzK1E8oe5iHVvsmkWVOxU1526bz60V6fpl8WfGVO3BrXFnlbk1sF2pTazojnyAOibMM8Yv4uLn2qWsUZVddC42HcEjUZeTV2aoPuHDz4S6LQM1VAj6kKSc0RkP4nxqAZ3vbUsve_y_I-Xfl5G_lX-2ONDuCxw5KstPO9k_gga2ewnjecVHfnbDl8GlVc8LGbD6wVN89g8UccfNPyTR9t1g58tyG1SWTDUakaq2Z1GvD1hVDIVKaNW3ZVkUyCBvZZ1rUK7bpW4A9h8vZdPnp3HcNFnzNI7H1lcpKxBfC5tpwFWgMh9Ncq9gqo4RJMluaEg0pchVKzTGMtlqlJQZYkVYIBFT8Ag6qurKvgOETaRIYLVUsk1gKNEYeqyjVCgMWEcUeTHbvt9COfZyaYPwowh3h-B8W8eBD_8SmY964R_aMTNbLEWd2O1DfXBVuChaxzsPEBklqEELlWhC0RQ81WgWhEsp6cLwzeOEmclMMbufBu_42TkHKq8jK1rdNgSCZRxlKRR687Pyj1wQD0pRglwfZnufsqbp_p1p_b2m-MVRGMMY9GJOPDSr97yW8vl__N_AIwZ7ojo-O4WB7c2vfIqDaqlE7a0ZweDpbfFvi9Wx6MV-M2uMJ_J3Ogl9PLR-M
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9NAEB6V8gAviBtDgUWCSEi14mvt9QNCXCWlhyKUSnkzexkigR3qVCh_it_IjE_C0be-Ret1NNqd2fk-z-wMwNPIaM0ND10Z5bEbUfQw9a12TSTzlJKb0rpN59FxPDmJPsz5fAt-dndhKK2yOxPrg9qUmr6RjxGHhEmC-EW8XH53qWsURVe7FhqNWhzY9Q-kbNWL_be4v8-CYO_d7M3EbbsKuJoHYuUqleToVIVNteHK08gB41Sr0CqjhIkSm5scpRep8qXmyB2tVnGOrCLQCr2fCvF_L8FldLwekb1k3hM8dHa8jVpQMxePD2HRMY3REP6mhuPJhhusuwX8C-L-nan5W7pZ7QH3rsO1FrqyV42u3YAtW9yE0bSpfb3eZbPhKle1y0ZsOlTFXt-Cj1PE6d8k03RPsmiL9VaszJmskAGrhWZSLwxbFAwnkdCsqtPECpqDMJW9JydSsGXfcuw2nFzI0t-B7aIs7D1g-EYceUZLFcoolCLlCLRUEGuFBEkEoQPjbn0z3VY7p6YbXzO_K3D-x4448Lx_Y9lU-jhn7mvasn4e1eiuB8rTz1lr8lmoUz-yXhQbhGypFgSl0SKMVp6vhLIO7HQbnrUHR5UNau7Ak_4xmjzFcWRhy7MqQ1DOgwRnBQ7cbfSjlwQJcEwwz4FkQ3M2RN18Uiy-1GXFkZoj-OMOjEjHBpH-twj3z5f_MVyZzI4Os8P944MHcBWBpmg-Xe3A9ur0zD5EMLdSj2oLYvDpok32F7RaWYU
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VVEJcEG8MBRYJIiHVjR-79vrQQ6GElkIVVanozezLEKl1ojoVyo_iP3bWXjuEAuLSWxSPk9HujOf7PLMzAK-oVoppFvuCFolPbfYwC43yNRVFZoubsnpM5-fDZO-YfjxhJ2vwsz0L41aw2rJlVahR_bC23j3TxcDlGAdomLaPCMPPdnp36moqD8ziBzK2ant_F7f3dRQN34_f7fluqICvWMTnvpRpgTGVm0xpJgOFFDDJlIyN1JJrmppCF6g8z2QoFEPqaJRMCiQVkZIY_GSMv3sD1ilFTtmD9Z3h0Zdx--jHaMdc2sJOcwnYMi96ReeVOFiPC_gTxr1aqvlLvVkdAod34LbDrmSnMba7sGbKe9AfNc2vF5tkvDzLVW2SPhkt22Iv7sPRCIH6mSDKHpQsXbfeikwLIiqkwHKiiFATTSYlQSGrNKnqOrHSyiBOJR9sFCnJrJs59gCOr2XxH0KvnJbmMRC8I6GBVkLGgsaCZwyRlowSJZEh8Sj2YNCub65cu3M7deM0D9sO57_tiAdvujtmTauPf8i-tVvWydkm3fUX0_NvufP5PFZZSE1AE42YLVPcYml0Ca1kEEoujQcb7Ybnrd3nKBPjn4SMe_Cyu4w-bxM5ojTTiypHVM6iFKUiDx419tFpggw4sTjPg3TFclZUXb1STr7XfcWRmyP6Yx70rY0tVfrbIjz5X8EXcHO0O8w_7R8ePIVbCDl58xJrA3rz8wvzDGHdXD53zkTg63X77yXr7FhZ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Plasma+concentrations+of+ascorbic+acid+in+a+cross+section+of+the+German+population&rft.jtitle=Journal+of+international+medical+research&rft.au=Hagel%2C+Alexander+F&rft.au=Albrecht%2C+Heinz&rft.au=Dauth%2C+Wolfgang&rft.au=Hagel%2C+Wolfgang&rft.date=2018-01-01&rft.eissn=1473-2300&rft.volume=46&rft.issue=1&rft.spage=168&rft_id=info:doi/10.1177%2F0300060517714387&rft_id=info%3Apmid%2F28760081&rft.externalDocID=28760081
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-0605&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-0605&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-0605&client=summon