The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168

• Published in: Nature cell biology Vol. 20; no. 3; pp. 320 - 331
• Main Authors: Xie, Xiaoduo, Hu, Hongli, Tong, Xinyuan, Li, Long, Liu, Xiangyuan, Chen, Min, Yuan, Huairui, Xie, Xia, Li, Qingrun, Zhang, Yuxue, Ouyang, Huafang, Wei, Mengqi, Huang, Jing, Liu, Pengda, Gan, Wenjian, Liu, Yong, Xie, Anyong, Kuai, Xiaoling, Chirn, Gung-Wei, Zhou, Hu, Zeng, Rong, Hu, Ronggui, Qin, Jun, Meng, Fei-Long, Wei, Wenyi, Ji, Hongbin, Gao, Daming
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2018
• Subjects: A549 Cells; Animals; Cell Proliferation; Control stability; Damage accumulation; Defects; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; DNA damage; DNA Repair; Female; Gene expression; Genomes; Genomic instability; Growth factors; HCT116 Cells; HEK293 Cells; Humans; Liver; LKB1 protein; Male; Mechanistic Target of Rapamycin Complex 1 - genetics; Mechanistic Target of Rapamycin Complex 1 - metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Neoplasms - enzymology; Neoplasms - genetics; Neoplasms - pathology; Nutrients; Phosphorylation; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proteolysis; Rapamycin; Ribosomal protein S6 kinase; Ribosomal Protein S6 Kinases, 70-kDa - genetics; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Ribosomal Protein S6 Kinases, 90-kDa - genetics; Ribosomal Protein S6 Kinases, 90-kDa - metabolism; Signal Transduction; Signaling; Stability; TOR protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tumor Burden; Tumorigenesis; Tumors; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism

Growth signals, such as extracellular nutrients and growth factors, have substantial effects on genome integrity; however, the direct underlying link remains unclear. Here, we show that the mechanistic target of rapamycin (mTOR)-ribosomal S6 kinase (S6K) pathway, a central regulator of growth signal...