SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons - Zaslavsky, Kirill; Zhang, Wen-Bo; McCready, Fraser P.; Rodrigues, Deivid C.; Deneault, Eric; Loo, Caitlin; Zhao, Melody; Ross, P. Joel; El Hajjar, Joelle; Romm, Asli; Thompson, Tadeo; Piekna, Alina; et al. (Nature neuroscience, 2019)
Keywords: 13; 13/100; 14; 14/19; 38/91; 42; 42/41; 45/23; 631/378/2571; 631/378/2583; 631/378/87; 82; 82/80; 9/74; Animal Genetics and Genomics; Autism; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - metabolism; Autism Spectrum Disorder - pathology; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Brain-derived neurotrophic factor; Coculture Techniques; Dendrites - metabolism; Dendrites - pathology; Dendritic structure; Excitatory Postsynaptic Potentials; Gene expression; Gene Knockout Techniques; Genetic aspects; Genetic modification; Haploinsufficiency; Health aspects; Humans; Induced Pluripotent Stem Cells; Insulin-like growth factor I; Male; Morphogenesis; Mutation; Neomycin; Nerve Tissue Proteins - genetics; Neural networks; Neurobiology; Neurogenesis; Neuronal Plasticity; Neurons; Neurons - metabolism; Neurons - pathology; Neurosciences; Novels; Pluripotency; Stem cell transplantation; Stem cells; Synapses; Transcription (Genetics); Transcriptome; Canada