Species tropism of HIV-1 modulated by viral accessory proteins

• Published in: Frontiers in microbiology Vol. 3; p. 267
• Main Authors: Nomaguchi, Masako, Doi, Naoya, Matsumoto, Yui, Sakai, Yosuke, Fujiwara, Sachi, Adachi, Akio
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 01.01.2012; Frontiers Media S.A
• Subjects: accessory protein; HIV-1; Microbiology; species tropism; Vif; Vpu; HIV-1; Vif; Vpu; species tropism; accessory protein

Human immunodeficiency virus type 1 (HIV-1) is tropic and pathogenic only for humans, and does not replicate in macaque monkeys routinely used for experimental infections. This specially narrow host range (species tropism) has impeded much the progress of HIV-1/acquired immunodeficiency syndrome (AI...