Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution

• Published in: BMC genomics Vol. 16; no. 1; p. 672
• Main Authors: Gross, Jeffrey A, Pacis, Alain, Chen, Gary G, Barreiro, Luis B, Ernst, Carl, Turecki, Gustavo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.09.2015; BioMed Central
• Subjects: 5-Methylcytosine - analogs & derivatives; Adult; Base Pairing; Binding Sites - genetics; Chromosomes, Human - metabolism; Cluster Analysis; Cytosine - analogs & derivatives; Cytosine - metabolism; Epigenesis, Genetic; Exons - genetics; Female; Gene Ontology; Genes; Genetic aspects; Genome, Human; Genomics; Humans; Introns - genetics; Male; Mental illness; Prefrontal Cortex - metabolism; Protein Processing, Post-Translational; Risk factors; Sequence Analysis, DNA; Sex Characteristics; X Chromosome Inactivation - genetics

The recent discovery that methylated cytosines are converted to 5-hydroxymethylated cytosines (5hmC) by the family of ten-eleven translocation enzymes has sparked significant interest on the genomic location, the abundance in different tissues, the putative functions, and the stability of this epige...