Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees

Radiation therapy (RT) is an integral component of potentially curative management of esophageal cancer (EC). However, RT can cause significant acute and late morbidity due to excess radiation exposure to nearby critical organs, especially the heart and lungs. Sparing these organs from both low and...

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Published inFrontiers in oncology Vol. 11; p. 748331
Main Authors Chuong, Michael D, Hallemeier, Christopher L, Li, Heng, Zhu, Xiaorong Ronald, Zhang, Xiaodong, Tryggestad, Erik J, Yu, Jen, Yang, Ming, Choi, J Isabelle, Kang, Minglei, Liu, Wei, Knopf, Antje, Meijers, Arturs, Molitoris, Jason K, Apisarnthanarax, Smith, Giap, Huan, Hoppe, Bradford S, Lee, Percy, Chang, Joe Y, Simone, 2nd, Charles B, Lin, Steven H
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.10.2021
Subjects
chemoradiation
esophageal cancer
Oncology
passive scatter proton
pencil beam scanning
proton beam therapy (PBT)
passive scatter proton
pencil beam scanning
esophageal cancer
chemoradiation
proton beam therapy (PBT)
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Abstract Radiation therapy (RT) is an integral component of potentially curative management of esophageal cancer (EC). However, RT can cause significant acute and late morbidity due to excess radiation exposure to nearby critical organs, especially the heart and lungs. Sparing these organs from both low and high radiation dose has been demonstrated to achieve clinically meaningful reductions in toxicity and may improve long-term survival. Accruing dosimetry and clinical evidence support the consideration of proton beam therapy (PBT) for the management of EC. There are critical treatment planning and delivery uncertainties that should be considered when treating EC with PBT, especially as there may be substantial motion-related interplay effects. The Particle Therapy Co-operative Group Thoracic and Gastrointestinal Subcommittees jointly developed guidelines regarding patient selection, treatment planning, clinical trials, and future directions of PBT for EC.
AbstractList Radiation therapy (RT) is an integral component of potentially curative management of esophageal cancer (EC). However, RT can cause significant acute and late morbidity due to excess radiation exposure to nearby critical organs, especially the heart and lungs. Sparing these organs from both low and high radiation dose has been demonstrated to achieve clinically meaningful reductions in toxicity and may improve long-term survival. Accruing dosimetry and clinical evidence support the consideration of proton beam therapy (PBT) for the management of EC. There are critical treatment planning and delivery uncertainties that should be considered when treating EC with PBT, especially as there may be substantial motion-related interplay effects. The Particle Therapy Co-operative Group Thoracic and Gastrointestinal Subcommittees jointly developed guidelines regarding patient selection, treatment planning, clinical trials, and future directions of PBT for EC.
Author Tryggestad, Erik J
Zhu, Xiaorong Ronald
Li, Heng
Liu, Wei
Choi, J Isabelle
Knopf, Antje
Giap, Huan
Yu, Jen
Kang, Minglei
Meijers, Arturs
Apisarnthanarax, Smith
Simone, 2nd, Charles B
Zhang, Xiaodong
Hoppe, Bradford S
Hallemeier, Christopher L
Lin, Steven H
Molitoris, Jason K
Chuong, Michael D
Lee, Percy
Yang, Ming
Chang, Joe Y
AuthorAffiliation 8 Department of Radiation Oncology, University of Maryland , Baltimore, Baltimore, MD , United States
9 Department of Radiation Oncology, University of Washington , Seattle, WA , United States
3 Department of Radiation Oncology, Johns Hopkins University , Baltimore, MD , United States
10 Department of Radiation Oncology, University of Miami , Miami, FL , United States
2 Department of Radiation Oncology, Mayo Clinic , Rochester, MN , United States
5 Department of Radiation Oncology, New York Proton Center , New York, NY , United States
4 Department of Radiation Oncology, MD Anderson Cancer Center , Houston, TX , United States
6 Department of Radiation Oncology, Mayo Clinic , Scottsdale, AZ , United States
7 Department of Radiation Oncology, University of Groningen , Groningen , Netherlands
11 Department of Radiation Oncology, Mayo Clinic , Jacksonville, FL , United States
1 Department of Radiation Oncology, Miami Cancer Institute , Miami, FL , United States
AuthorAffiliation_xml – name: 11 Department of Radiation Oncology, Mayo Clinic , Jacksonville, FL , United States
– name: 3 Department of Radiation Oncology, Johns Hopkins University , Baltimore, MD , United States
– name: 4 Department of Radiation Oncology, MD Anderson Cancer Center , Houston, TX , United States
– name: 10 Department of Radiation Oncology, University of Miami , Miami, FL , United States
– name: 6 Department of Radiation Oncology, Mayo Clinic , Scottsdale, AZ , United States
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Copyright Copyright © 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin.
Copyright © 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin
Copyright_xml – notice: Copyright © 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin.
– notice: Copyright © 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin
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Keywords passive scatter proton
pencil beam scanning
esophageal cancer
chemoradiation
proton beam therapy (PBT)
Language English
License Copyright © 2021 Chuong, Hallemeier, Li, Zhu, Zhang, Tryggestad, Yu, Yang, Choi, Kang, Liu, Knopf, Meijers, Molitoris, Apisarnthanarax, Giap, Hoppe, Lee, Chang, Simone and Lin.
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Edited by: Toshikazu Moriwaki, University of Tsukuba, Japan
Reviewed by: Hitoshi Ishikawa, National Institutes for Quantum and Radiological Science and Technology, Japan; Steven Maron, Memorial Sloan Kettering Cancer Center, United States
This article was submitted to Gastrointestinal Cancers: Gastric and Esophageal Cancers, a section of the journal Frontiers in Oncology
These authors share first authorship
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Snippet Radiation therapy (RT) is an integral component of potentially curative management of esophageal cancer (EC). However, RT can cause significant acute and late...
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SubjectTerms chemoradiation
esophageal cancer
Oncology
passive scatter proton
pencil beam scanning
proton beam therapy (PBT)
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Title Executive Summary of Clinical and Technical Guidelines for Esophageal Cancer Proton Beam Therapy From the Particle Therapy Co-Operative Group Thoracic and Gastrointestinal Subcommittees
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