Ulinastatin Reduces Cancer Recurrence after Resection of Hepatic Metastases from Colon Cancer by Inhibiting MMP-9 Activation via the Antifibrinolytic Pathway

• Published in: BioMed research international Vol. 2013; no. 2013; pp. 1 - 10
• Main Authors: Jia, Lin, Li, Jiang-lin, Cai, Wen-song, Xiao, Huan-qing, Shen, Fei, Li, Kun-ping, Xu, Bo, Liu, Qi-cai
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2013; John Wiley & Sons, Inc
• Subjects: Animal models; Animals; Cancer; Colleges & universities; Colon; Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Colorectal cancer; Drug therapy; Glycoproteins - administration & dosage; HCT116 Cells; Humans; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Liver Neoplasms - surgery; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors - administration & dosage; Mice; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Physiological aspects; Proteases; Relapse; Risk factors; Rodents; China

High recurrence of colon cancer liver metastasis is observed in patients after hepatic surgery, and the cause is believed to be mostly due to the growth of residual microscopic metastatic lesions within the residual liver. Therefore, triggering the progression of occult metastatic foci may be a nove...