Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

• Published in: Frontiers in immunology Vol. 10; p. 2797
• Main Authors: Wang, Li-Xue, Zhu, Xiao-Mei, Yao, Yong-Ming
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.12.2019
• Subjects: autophagy; endoplasmic reticulum stress; immune cell; immune response; Immunology; Sestrin2; immune cell; Sestrin2; autophagy; immune response; endoplasmic reticulum stress

Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and infla...