Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and infla...

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Published inFrontiers in immunology Vol. 10; p. 2797
Main Authors Wang, Li-Xue, Zhu, Xiao-Mei, Yao, Yong-Ming
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.12.2019
Subjects
autophagy
endoplasmic reticulum stress
immune cell
immune response
Immunology
Sestrin2
immune cell
Sestrin2
autophagy
immune response
endoplasmic reticulum stress
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Summary:Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation. In recent years, breakthrough investigations with regard to the regulation and signaling mechanisms of SESN2 have markedly deepened our understanding of its potential role as well as its significance in host response. However, the functions of SESN2 in the immune system and inflammation remain elusive. It has been documented that many immune cells positively express SESN2 and, in turn, that SESN2 might modulate cellular activities. This review incorporates recent progress and aims to provide novel insight into the protective role and regulatory pathway of SESN2, which acts as a potential biomarker and therapeutic target in the context of various diseases.
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Edited by: Haichao Wang, Feinstein Institute for Medical Research, United States
These authors have contributed equally to this work
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Nina Zeng, The University of Auckland, New Zealand; Luiz Eduardo Baggio Savio, Federal University of Rio de Janeiro, Brazil
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02797