Linkage of lncRNA CRNDE sponging miR-181a-5p with aggravated inflammation underlying sepsis

• Published in: Innate immunity (London, England) Vol. 26; no. 2; pp. 152 - 161
• Main Authors: Wang, Yijun, Xu, Ziqiang, Yue, Dongyou, Zeng, Zhenhua, Yuan, Weijie, Xu, Ke
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.02.2020; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Adolescent; Adult; Aged; Cell Line; Cytokines - blood; Cytokines - genetics; Down-Regulation; Female; Humans; IL-1β; Inflammation; Inflammation - blood; Inflammation - genetics; Inflammation - metabolism; Interleukin 6; Interleukin-1beta - blood; Interleukin-1beta - genetics; Interleukin-6 - genetics; Interleukin-6 - metabolism; Life span; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Macrophages - drug effects; Macrophages - metabolism; Male; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; NF-kappa B - blood; NF-kappa B - genetics; NF-κB protein; Original; Peripheral blood; Prognosis; Reporter gene; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; RNA, Small Interfering; Sepsis; Sepsis - blood; Sepsis - genetics; Sepsis - physiopathology; TLR4 protein; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - genetics; Tumor necrosis factor-α; Up-Regulation; Sepsis; LncRNA CRNDE; miR-181a-5p; inflammation; TLR4

This investigation was performed to verify whether lncRNA CRNDE sponging miR-181a-5p was involved with sepsis-relevant inflammatory dysfunctions. Aggregately 136 sepsis patients and 151 healthy people were recruited, and their fasting peripheral blood was gathered to detect expressions of CRNDE and...