Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications i...

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Published inNanomedicine (London, England) Vol. 10; no. 8; pp. 1315 - 1326
Main Authors Nicol, James R, Dixon, Dorian, Coulter, Jonathan A
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.04.2015
Subjects
Analysis
Animals
bottom-up synthesis
Cancer
Care and treatment
Diagnostic Imaging - methods
Drug Delivery Systems - methods
gold
Gold - chemistry
Gold - pharmacokinetics
Gold - therapeutic use
Gold - toxicity
Humans
Life expectancy
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Metal Nanoparticles - toxicity
Metal Nanoparticles - ultrastructure
Nanomedicine
Nanomedicine - methods
nanoparticle
nanoparticle functionalization
nanoparticle stability
Nanotechnology - methods
Neoplasms - therapy
organelle targeting
Risk factors
Therapeutics
gold
nanoparticle
nanoparticle functionalization
organelle targeting
bottom–up synthesis
nanoparticle stability
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Abstract With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
AbstractList With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
Audience Academic
Author Dixon, Dorian
Nicol, James R
Coulter, Jonathan A
AuthorAffiliation 1School of Pharmacy, McClay Research Centre, Queen's University Belfast, Belfast, UK
2School of Engineering, Jordanstown Campus, University of Ulster, Jordanstown, UK
AuthorAffiliation_xml – name: 1School of Pharmacy, McClay Research Centre, Queen's University Belfast, Belfast, UK
– name: 2School of Engineering, Jordanstown Campus, University of Ulster, Jordanstown, UK
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  surname: Nicol
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– sequence: 3
  givenname: Jonathan A
  surname: Coulter
  fullname: Coulter, Jonathan A
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25955125$$D View this record in MEDLINE/PubMed
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Snippet With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents....
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SubjectTerms Analysis
Animals
bottom-up synthesis
Cancer
Care and treatment
Diagnostic Imaging - methods
Drug Delivery Systems - methods
gold
Gold - chemistry
Gold - pharmacokinetics
Gold - therapeutic use
Gold - toxicity
Humans
Life expectancy
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Metal Nanoparticles - toxicity
Metal Nanoparticles - ultrastructure
Nanomedicine
Nanomedicine - methods
nanoparticle
nanoparticle functionalization
nanoparticle stability
Nanotechnology - methods
Neoplasms - therapy
organelle targeting
Risk factors
Therapeutics
Title Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics
URI http://dx.doi.org/10.2217/nnm.14.219
https://www.ncbi.nlm.nih.gov/pubmed/25955125
https://www.proquest.com/docview/1698456240
https://www.proquest.com/docview/1680180561
https://www.proquest.com/docview/1846408540
Volume 10
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