Evidence of newly generated neurons in the human olfactory bulb

• Published in: Brain research. Developmental brain research Vol. 151; no. 1; pp. 159 - 168
• Main Authors: Bédard, Andréanne, Parent, André
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 19.07.2004
• Subjects: Adult; Adult neurogenesis; Aged; Alcohol Oxidoreductases - metabolism; Basic Helix-Loop-Helix Transcription Factors; Brain development; Calbindin 2; Cell Division; Female; Glutamate Decarboxylase - metabolism; Human brain; Humans; Immunohistochemistry - methods; Intermediate Filament Proteins - metabolism; Isoenzymes - metabolism; Ki-67 Antigen - metabolism; Male; Middle Aged; Nerve Tissue Proteins - metabolism; Nestin; Neural Cell Adhesion Molecule L1 - metabolism; Neurons - metabolism; Olfactory Bulb - cytology; Olfactory system; Parvalbumins - metabolism; Postmortem Changes; Primates; Proliferating Cell Nuclear Antigen - metabolism; Rostral migratory stream; S100 Calcium Binding Protein G - metabolism; Sialic Acids - metabolism; Stem cell; Sugar Alcohol Dehydrogenases; Tubulin - metabolism; Tyrosine 3-Monooxygenase - metabolism; EPL; Rostral migratory stream; PCNA; Adult neurogenesis; Stem cell; PV; Brain development; LV; ONL; Olfactory system; OB; SVZ; Human brain; OP; GL; Sensory systems; Olfactory senses; GAD; CR; GFAP; TuJ1; GCL; TH; MCL; DCX; RMS; PSA-NCAM
• ISSN: 0165-3806
• DOI: 10.1016/j.devbrainres.2004.03.021

The subventricular zone (SVZ) is known to be the major source of neural stem cells in the adult brain. In rodents and nonhuman primates, many neuroblasts generated in the SVZ migrate in chains along the rostral migratory stream (RMS) to populate the olfactory bulb (OB) with new granular and periglom...