Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects

• Published in: Frontiers in immunology Vol. 9; p. 996
• Main Authors: Calise, Justine, Marquez Renteria, Susana, Gregersen, Peter K., Diamond, Betty
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.05.2018
• Subjects: Adolescent; Adult; Apoptosis; Autoimmunity; B lymphocytes; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; Case-Control Studies; Cell Line; Female; Gene Expression; Genetic Predisposition to Disease; genetics; Genotype; Haplotypes; Humans; Imidazoles - pharmacology; Immunology; Interferon Regulatory Factors - genetics; lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Male; Middle Aged; monocytes; Oligodeoxyribonucleotides - pharmacology; Risk Factors; Young Adult; monocytes; haplotypes; genetics; autoimmunity; B lymphocytes; lupus

Interferon regulatory factor 5 (IRF5) is widely recognized as a risk locus for systemic lupus erythematosus (SLE). Risk gene and IRF5 activation is triggered through toll-like receptor signaling. In myeloid cells, this leads to production of type I interferon and inflammatory cytokines, with enhance...