Continuously updated network meta-analysis and statistical monitoring for timely decision-making

• Published in: Statistical methods in medical research Vol. 27; no. 5; pp. 1312 - 1330
• Main Authors: Nikolakopoulou, Adriani, Mavridis, Dimitris, Egger, Matthias, Salanti, Georgia
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2018
• Subjects: Data Interpretation, Statistical; Decision Making; Diabetes Complications - surgery; Humans; Network Meta-Analysis As Topic; Percutaneous Coronary Intervention; Prospective Studies; Statistics as Topic; Systematic Reviews as Topic; Sequential methods; stopping rules; multiple treatments; update of systematic reviews; efficacy and futility boundaries

Pairwise and network meta-analysis (NMA) are traditionally used retrospectively to assess existing evidence. However, the current evidence often undergoes several updates as new studies become available. In each update recommendations about the conclusiveness of the evidence and the need of future s...