Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells

• Published in: Frontiers in pharmacology Vol. 8; p. 244
• Main Authors: Lv, Chaoxiang, Qu, Hao, Zhu, Wanyun, Xu, Kaixiang, Xu, Anyong, Jia, Baoyu, Qing, Yubo, Li, Honghui, Wei, Hong-Jiang, Zhao, Hong-Ye
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.05.2017
• Subjects: cell growth; colorectal carcinoma cells; glutaminolysis; lactate production; low-dose PTX; Pharmacology; cell growth; low-dose PTX; lactate production; colorectal carcinoma cells; glutaminolysis

Paclitaxel (PTX) is a natural alkaloid isolated from the bark of a tree, , and is currently used to treat a variety of tumors. Recently, it has been found that low-dose PTX is a promising treatment for some cancers, presenting few side effects. However, antitumor mechanisms of low-dose PTX (<1 nM...