Tocilizumab in the treatment of severe and refractory parenchymal neuro-Behçet’s syndrome: case series and literature review

• Published in: Therapeutic advances in musculoskeletal disease Vol. 12; p. 1759720X20971908
• Main Authors: Liu, Jinjing, Yan, Dong, Wang, Zhimian, Yang, Yunjiao, Zhang, Shangzhu, Wu, Di, Peng, Lingyi, Liu, Zhichun, Zheng, Wenjie
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 2020; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Case Series; Clinical outcomes; Cytokines; Immunosuppressive agents; Immunotherapy; Inflammatory diseases; Monoclonal antibodies; Neurological disorders; Vein & artery diseases; Behçet’s syndrome; tocilizumab; neurological involvement

Objectives: This study aimed to investigate the efficacy and safety of tocilizumab (TCZ) in severe and refractory parenchymal neuro-Behçet’s syndrome (p-NBS). Methods: We retrospectively analyzed five patients with p-NBS treated with TCZ in our center between 2013 and 2020, and six cases from litera...