Pancreatic Stellate Cells Facilitate Perineural Invasion of Pancreatic Cancer via HGF/c-Met Pathway

• Published in: Cell transplantation Vol. 28; no. 9-10; pp. 1289 - 1298
• Main Authors: Nan, Ligang, Qin, Tao, Xiao, Ying, Qian, Weikun, Li, Jie, Wang, Zheng, Ma, Jiguang, Ma, Qingyong, Wu, Zheng
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.09.2019; Sage Publications Ltd; SAGE Publishing
• Subjects: c-Met protein; Cell adhesion & migration; Cell culture; Cell migration; Dorsal root ganglia; Gelatinase B; Growth factors; Hepatocyte growth factor; Matrix metalloproteinase; Metalloproteinase; Metastases; Metastasis; Nerve growth factor; Original; Pancreatic cancer; Pheochromocytoma cells; Signal transduction; siRNA; Stellate cells; Therapeutic applications; perineural invasion; pancreatic stellate cells; pancreatic cancer; HGF/c-Met pathway

Pancreatic cancer (PC) is a highly lethal cancer that has a strong ability for invasion and metastasis, poor prognosis, and a stubbornly high death rate due to late diagnosis and early metastasis. Therefore, a better understanding of the mechanisms of metastasis should provide novel opportunities fo...