Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis of Adult-Onset Still’s Disease

• Published in: Frontiers in immunology Vol. 11; p. 2112
• Main Authors: Sun, Yue, Wang, Fan, Zhou, Zhuochao, Teng, Jialin, Su, Yutong, Chi, Huihui, Wang, Zhihong, Hu, Qiongyi, Jia, Jinchao, Liu, Tingting, Liu, Honglei, Cheng, Xiaobing, Shi, Hui, Tan, Yun, Yang, Chengde, Ye, Junna
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.09.2020
• Subjects: Adult; adult-onset Still’s disease; Aged; biomarker; Biomarkers - urine; Chromatography, Liquid; Female; Humans; Immunity, Innate; Immunology; Male; Middle Aged; orosomucoid; Proteomics; Still's Disease, Adult-Onset - immunology; Still's Disease, Adult-Onset - urine; Tandem Mass Spectrometry; urinary proteomics; α-1-acid glycoprotein 1; α-1-acid glycoprotein 1; adult-onset Still’s disease; urinary proteomics; orosomucoid; biomarker

Adult-onset Still's disease (AOSD) is a systemic, multigenic autoinflammatory disease, and the diagnosis of AOSD must rule out neoplasms, infections, and other autoimmune diseases. Development of a rapid and efficient but non-invasive diagnosis method is urgently needed for improving AOSD thera...