Cytogenomic Evaluation of Subjects with Syndromic and Nonsyndromic Conotruncal Heart Defects

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 12
• Main Authors: Campos Pellanda, Lucia, Huber, Janaina, Mergener, Rafaella, de Souza, Karen Regina, Riegel, Mariluce
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc
• Subjects: Adolescent; Adult; Cardiology; Child; Child, Preschool; Chromosome Aberrations; Comparative Genomic Hybridization; Congenital diseases; Congenital heart disease; Data analysis; DNA Copy Number Variations - genetics; Experiments; Female; Genetic testing; Genomes; Heart; Heart Defects, Congenital - etiology; Heart Defects, Congenital - genetics; Heart Defects, Congenital - pathology; Humans; Infant; Infant, Newborn; Male; Physiological aspects; Schizophrenia; Software; Brazil; Rio Grande do Sul Brazil; United States > US
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2015/401941

Despite considerable advances in the detection of genomic abnormalities in congenital heart disease (CHD), the etiology of CHD remains largely unknown. CHD is the most common birth defect and is a major cause of infant morbidity and mortality, and conotruncal defects constitute 20% of all CHD cases....