Interplay between Replication and Recombination in Escherichia coli: Impact of the Alternative DNA Polymerases

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 12; pp. 4564 - 4569
• Main Authors: Delmas, Stéphane, Matic, Ivan
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 21.03.2006; National Acad Sciences
• Subjects: Alleles; Bacteria; Biological Sciences; Cells; Chromosomes; Chromosomes, Bacterial - genetics; Chromosomes, Bacterial - metabolism; Deoxyribonucleic acid; DNA; DNA Polymerase beta - metabolism; DNA Polymerase III - metabolism; DNA repair; DNA Replication; DNA-Directed DNA Polymerase - metabolism; E coli; Enzymes; Escherichia coli; Escherichia coli - enzymology; Escherichia coli - genetics; Escherichia coli Proteins - metabolism; Genes; Genetic recombination; Genetic SOS response; Genetics; Kinetics; Lesions; Recombination, Genetic

Homologous recombination (HR) and translesion synthesis (TLS) are two pathways involved in the tolerance of lesions that block the replicative DNA polymerase. However, whereas TLS is frequently error-prone and, therefore, can be deleterious, HR is generally error-free. Furthermore, because the recom...