Modulation of natriuretic peptide receptors in human adipose tissue: molecular mechanisms behind the “natriuretic handicap” in morbidly obese patients

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 186; pp. 52 - 61
• Main Authors: Gentili, Alessandra, Frangione, Maria Rosaria, Albini, Elisa, Vacca, Carmine, Ricci, Maria Anastasia, De Vuono, Stefano, Boni, Marcello, Rondelli, Fabio, Rotelli, Luciana, Lupattelli, Graziana, Orabona, Ciriana
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2017
• Subjects: Adipocytes; Adipose Tissue - metabolism; Adult; Case-Control Studies; Female; Gene Expression Regulation - physiology; Humans; Interleukin-6 - metabolism; Interleukin-6 - pharmacology; Internal Medicine; Male; Middle Aged; Natriuretic Peptide, Brain - genetics; Natriuretic Peptide, Brain - metabolism; Obesity, Morbid - metabolism; Receptors, Atrial Natriuretic Factor - genetics; Receptors, Atrial Natriuretic Factor - metabolism; NP; SVF; BNP; AF; SAT; VAT; GPT; GOT; TC; NPR; HDL; AT; AU; LDL; GGT; HOMA; BMI; Low-Density lipoprotein-cholesterol; Gamma-Glutamyl Transpeptidase; B-type Natriuretic Peptide; Natriuretic Peptide Receptor; Stroma-vascular fraction; High-Density Lipoprotein-cholesterol; Arbitrary Units; Glutamic Oxaloacetic Transaminase; Adipose Tissue; Natriuretic Peptide; Homeostasis Model Assessment of Insulin resistance; Total Cholesterol; Body Mass Index; Glutamic-Pyruvic Transaminase; Adipose fraction; Subcutaneous Adipose Tissue; Visceral Adipose Tissue

The B-type natriuretic peptide (BNP) hormone plays a crucial role in the regulation of cardiovascular and energy homeostasis. Obesity is associated with low circulating levels of BNP, a condition known as “natriuretic handicap.” Recent evidences suggest an altered expression of BNP receptors—both th...