Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

• Published in: Frontiers in immunology Vol. 7; p. 52
• Main Authors: Romero-Garcia, Susana, Moreno-Altamirano, María Maximina B., Prado-Garcia, Heriberto, Sánchez-García, Francisco Javier
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.02.2016
• Subjects: immune escape; Immunology; L-lactate metabolism; monocarboxylate transporter; Tumor Microenvironment; Warburg effect; l-lactate metabolism; monocarboxylate transporter; immune escape; tumor microenvironment; Warburg effect

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a larger fraction of pyruvate into lactate, even under normoxic conditions; this phenomenon of aerobic glycolysis is largely known as the Warburg effect. This metabolic reprograming serves to generate biosynthet...