Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation

• Published in: Frontiers in immunology Vol. 11; p. 1205
• Main Authors: Guo-Parke, Hong, Linden, Dermot, Weldon, Sinéad, Kidney, Joseph C, Taggart, Clifford C
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.06.2020
• Subjects: acute pulmonary exacerbation; Biomarkers; chronic obstructive pulmonary disease; Disease Progression; Disease Susceptibility - immunology; ErbB Receptors - metabolism; Host-Pathogen Interactions - immunology; Humans; Immunology; infection; Inflammasomes - metabolism; inflammation; Inflammation Mediators - metabolism; lung damage; NF-kappa B - metabolism; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Respiratory Tract Infections - complications; Respiratory Tract Infections - immunology; Signal Transduction; Toll-Like Receptors - metabolism; virus; Virus Diseases - complications; Virus Diseases - immunology; acute pulmonary exacerbation; infection; inflammation; virus; chronic obstructive pulmonary disease; lung damage

Chronic obstructive pulmonary disease (COPD) is the integrated form of chronic obstructive bronchitis and pulmonary emphysema, characterized by persistent small airway inflammation and progressive irreversible airflow limitation. COPD is characterized by acute pulmonary exacerbations and associated...