Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A
The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pa...
Saved in:
Published in | BMC microbiology Vol. 15; no. 1; p. 206 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
09.10.2015
BioMed Central |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pathway on the secretome has not been investigated. In this study, we performed quantitative proteomics using galactose-inducible and glucose-repressible expression of the PKA1 gene encoding the catalytic subunit of PKA to identify regulated proteins in the secretome.
The proteins in the supernatants of cultures of C. neoformans were precipitated and identified using liquid chromatography-coupled tandem mass spectrometry. We also employed multiple reaction monitoring in a targeted approach to identify fungal proteins in samples from macrophages after phagocytosis of C. neoformans cells, as well as from the blood and bronchoalveolar fluid of infected mice.
We identified 61 secreted proteins and found that changes in PKA1 expression influenced the extracellular abundance of five proteins, including the Cig1 and Aph1 proteins with known roles in virulence. We also observed a change in the secretome profile upon induction of Pka1 from proteins primarily involved in catabolic and metabolic processes to an expanded set that included proteins for translational regulation and the response to stress. We further characterized the secretome data using enrichment analysis and by predicting conventional versus non-conventional secretion. Targeted proteomics of the Pka1-regulated proteins allowed us to identify the secreted proteins in lysates of phagocytic cells containing C. neoformans, and in samples from infected mice. This analysis also revealed that modulation of PKA1 expression influences the intracellular survival of cryptococcal cells upon phagocytosis.
Overall, we found that the cAMP/PKA pathway regulates specific components of the secretome including proteins that affect the virulence of C. neoformans. The detection of secreted cryptococcal proteins from infected phagocytic cells and tissue samples suggests their potential utility as biomarkers of infection. The proteomics data are available via ProteomeXchange with identifiers PXD002731 and PASS00736. |
---|---|
AbstractList | The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pathway on the secretome has not been investigated. In this study, we performed quantitative proteomics using galactose-inducible and glucose-repressible expression of the PKA1 gene encoding the catalytic subunit of PKA to identify regulated proteins in the secretome. The proteins in the supernatants of cultures of C. neoformans were precipitated and identified using liquid chromatography-coupled tandem mass spectrometry. We also employed multiple reaction monitoring in a targeted approach to identify fungal proteins in samples from macrophages after phagocytosis of C. neoformans cells, as well as from the blood and bronchoalveolar fluid of infected mice. We identified 61 secreted proteins and found that changes in PKA1 expression influenced the extracellular abundance of five proteins, including the Cig1 and Aph1 proteins with known roles in virulence. We also observed a change in the secretome profile upon induction of Pka1 from proteins primarily involved in catabolic and metabolic processes to an expanded set that included proteins for translational regulation and the response to stress. We further characterized the secretome data using enrichment analysis and by predicting conventional versus non-conventional secretion. Targeted proteomics of the Pka1-regulated proteins allowed us to identify the secreted proteins in lysates of phagocytic cells containing C. neoformans, and in samples from infected mice. This analysis also revealed that modulation of PKA1 expression influences the intracellular survival of cryptococcal cells upon phagocytosis. Overall, we found that the cAMP/PKA pathway regulates specific components of the secretome including proteins that affect the virulence of C. neoformans. The detection of secreted cryptococcal proteins from infected phagocytic cells and tissue samples suggests their potential utility as biomarkers of infection. The proteomics data are available via ProteomeXchange with identifiers PXD002731 and PASS00736. Background The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pathway on the secretome has not been investigated. In this study, we performed quantitative proteomics using galactose-inducible and glucose-repressible expression of the PKA1 gene encoding the catalytic subunit of PKA to identify regulated proteins in the secretome. Methods The proteins in the supernatants of cultures of C. neoformans were precipitated and identified using liquid chromatography-coupled tandem mass spectrometry. We also employed multiple reaction monitoring in a targeted approach to identify fungal proteins in samples from macrophages after phagocytosis of C. neoformans cells, as well as from the blood and bronchoalveolar fluid of infected mice. Results We identified 61 secreted proteins and found that changes in PKA1 expression influenced the extracellular abundance of five proteins, including the Cig1 and Aph1 proteins with known roles in virulence. We also observed a change in the secretome profile upon induction of Pka1 from proteins primarily involved in catabolic and metabolic processes to an expanded set that included proteins for translational regulation and the response to stress. We further characterized the secretome data using enrichment analysis and by predicting conventional versus non-conventional secretion. Targeted proteomics of the Pka1-regulated proteins allowed us to identify the secreted proteins in lysates of phagocytic cells containing C. neoformans, and in samples from infected mice. This analysis also revealed that modulation of PKA1 expression influences the intracellular survival of cryptococcal cells upon phagocytosis. Conclusions Overall, we found that the cAMP/PKA pathway regulates specific components of the secretome including proteins that affect the virulence of C. neoformans. The detection of secreted cryptococcal proteins from infected phagocytic cells and tissue samples suggests their potential utility as biomarkers of infection. The proteomics data are available via ProteomeXchange with identifiers PXD002731 and PASS00736. Keywords: Quantitative proteomics, Fungal pathogenesis, Secretome, PKA, Virulence factors, Biomarkers, Multiple reaction monitoring The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pathway on the secretome has not been investigated. In this study, we performed quantitative proteomics using galactose-inducible and glucose-repressible expression of the PKA1 gene encoding the catalytic subunit of PKA to identify regulated proteins in the secretome. The proteins in the supernatants of cultures of C. neoformans were precipitated and identified using liquid chromatography-coupled tandem mass spectrometry. We also employed multiple reaction monitoring in a targeted approach to identify fungal proteins in samples from macrophages after phagocytosis of C. neoformans cells, as well as from the blood and bronchoalveolar fluid of infected mice. We identified 61 secreted proteins and found that changes in PKA1 expression influenced the extracellular abundance of five proteins, including the Cig1 and Aph1 proteins with known roles in virulence. We also observed a change in the secretome profile upon induction of Pka1 from proteins primarily involved in catabolic and metabolic processes to an expanded set that included proteins for translational regulation and the response to stress. We further characterized the secretome data using enrichment analysis and by predicting conventional versus non-conventional secretion. Targeted proteomics of the Pka1-regulated proteins allowed us to identify the secreted proteins in lysates of phagocytic cells containing C. neoformans, and in samples from infected mice. This analysis also revealed that modulation of PKA1 expression influences the intracellular survival of cryptococcal cells upon phagocytosis. Overall, we found that the cAMP/PKA pathway regulates specific components of the secretome including proteins that affect the virulence of C. neoformans. The detection of secreted cryptococcal proteins from infected phagocytic cells and tissue samples suggests their potential utility as biomarkers of infection. The proteomics data are available via ProteomeXchange with identifiers PXD002731 and PASS00736. Background The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pathway on the secretome has not been investigated. In this study, we performed quantitative proteomics using galactose-inducible and glucose-repressible expression of the PKA1 gene encoding the catalytic subunit of PKA to identify regulated proteins in the secretome. Methods The proteins in the supernatants of cultures of C. neoformans were precipitated and identified using liquid chromatography-coupled tandem mass spectrometry. We also employed multiple reaction monitoring in a targeted approach to identify fungal proteins in samples from macrophages after phagocytosis of C. neoformans cells, as well as from the blood and bronchoalveolar fluid of infected mice. Results We identified 61 secreted proteins and found that changes in PKA1 expression influenced the extracellular abundance of five proteins, including the Cig1 and Aph1 proteins with known roles in virulence. We also observed a change in the secretome profile upon induction of Pka1 from proteins primarily involved in catabolic and metabolic processes to an expanded set that included proteins for translational regulation and the response to stress. We further characterized the secretome data using enrichment analysis and by predicting conventional versus non-conventional secretion. Targeted proteomics of the Pka1-regulated proteins allowed us to identify the secreted proteins in lysates of phagocytic cells containing C. neoformans, and in samples from infected mice. This analysis also revealed that modulation of PKA1 expression influences the intracellular survival of cryptococcal cells upon phagocytosis. Conclusions Overall, we found that the cAMP/PKA pathway regulates specific components of the secretome including proteins that affect the virulence of C. neoformans. The detection of secreted cryptococcal proteins from infected phagocytic cells and tissue samples suggests their potential utility as biomarkers of infection. The proteomics data are available via ProteomeXchange with identifiers PXD002731 and PASS00736. BACKGROUNDThe pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influence of the pathway on the secretome has not been investigated. In this study, we performed quantitative proteomics using galactose-inducible and glucose-repressible expression of the PKA1 gene encoding the catalytic subunit of PKA to identify regulated proteins in the secretome.METHODSThe proteins in the supernatants of cultures of C. neoformans were precipitated and identified using liquid chromatography-coupled tandem mass spectrometry. We also employed multiple reaction monitoring in a targeted approach to identify fungal proteins in samples from macrophages after phagocytosis of C. neoformans cells, as well as from the blood and bronchoalveolar fluid of infected mice.RESULTSWe identified 61 secreted proteins and found that changes in PKA1 expression influenced the extracellular abundance of five proteins, including the Cig1 and Aph1 proteins with known roles in virulence. We also observed a change in the secretome profile upon induction of Pka1 from proteins primarily involved in catabolic and metabolic processes to an expanded set that included proteins for translational regulation and the response to stress. We further characterized the secretome data using enrichment analysis and by predicting conventional versus non-conventional secretion. Targeted proteomics of the Pka1-regulated proteins allowed us to identify the secreted proteins in lysates of phagocytic cells containing C. neoformans, and in samples from infected mice. This analysis also revealed that modulation of PKA1 expression influences the intracellular survival of cryptococcal cells upon phagocytosis.CONCLUSIONSOverall, we found that the cAMP/PKA pathway regulates specific components of the secretome including proteins that affect the virulence of C. neoformans. The detection of secreted cryptococcal proteins from infected phagocytic cells and tissue samples suggests their potential utility as biomarkers of infection. The proteomics data are available via ProteomeXchange with identifiers PXD002731 and PASS00736. |
ArticleNumber | 206 |
Audience | Academic |
Author | Foster, Leonard J Geddes, Jennifer M H Croll, Daniel Kronstad, James W Stoynov, Nikolay Caza, Mélissa |
Author_xml | – sequence: 1 givenname: Jennifer M H surname: Geddes fullname: Geddes, Jennifer M H email: jenngedd13@gmail.com, jenngedd13@gmail.com organization: Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. jenngedd13@gmail.com – sequence: 2 givenname: Daniel surname: Croll fullname: Croll, Daniel email: daniel.croll@usys.ethz.ch organization: Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. daniel.croll@usys.ethz.ch – sequence: 3 givenname: Mélissa surname: Caza fullname: Caza, Mélissa email: mcaza@msl.ubc.ca organization: Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. mcaza@msl.ubc.ca – sequence: 4 givenname: Nikolay surname: Stoynov fullname: Stoynov, Nikolay email: nstoynov@mail.ubc.ca organization: Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. nstoynov@mail.ubc.ca – sequence: 5 givenname: Leonard J surname: Foster fullname: Foster, Leonard J email: foster@chibi.ubc.ca organization: Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. foster@chibi.ubc.ca – sequence: 6 givenname: James W surname: Kronstad fullname: Kronstad, James W email: kronstad@msl.ubc.ca, kronstad@msl.ubc.ca organization: Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. kronstad@msl.ubc.ca |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26453029$$D View this record in MEDLINE/PubMed |
BookMark | eNptks1u1DAUhSNURH_gAdigSGxgkWInjp1skEYjfipVQqKwthznOrhN7MF2Rsyz8LLcMNOqg5AXvpa_c2xfn_PsxHkHWfaSkktKG_4u0rLhvCC0LkhdlUX1JDujTNCipA05eVSfZucx3hJCRVOJZ9lpyVldkbI9y37fgA6Q_AT5JnhjR-uG3Jt8HXab5LXXeo65A298mJSLeYAtqHGZh3lUyXq30CqPcxchLfXWhnkEp6FQMXptVYJ-8U5gUa8cLrB2yaox76yfVLiDEPNudw_ld9apCPnqefbU4Fnw4jBfZN8_fvi2_lxcf_l0tV5dF7oum1QIVZbQCdMAZ0z0nSZdwwWjQEtjWs1o1zYUOtWDqltTQ881U6CZqERthKDVRfZ-77uZuwl6jZcLapSbYPFyO-mVlcc7zv6Qg99Kxgk2sUGDNweD4H_OEJOcbNQwjgo7N0dJRYm_wFveIvr6H_TWz8Hh85ASbcMI_2t4oAY1grTOeDxXL6ZyVTNaCdpWNVKX_6Fw9DBZjVHB74RjwdsjATIJfqVBzTHKq5uvxyzdszr4GAOYh35QIpf0yX36JKZPLumTFWpePW7kg-I-btUfjTjaIw |
CitedBy_id | crossref_primary_10_1021_jasms_3c00114 crossref_primary_10_1099_mic_0_000815 crossref_primary_10_3389_fcimb_2019_00212 crossref_primary_10_3390_jof8050527 crossref_primary_10_1074_jbc_RA119_008684 crossref_primary_10_1016_j_vaccine_2019_10_051 crossref_primary_10_1007_s00294_016_0578_2 crossref_primary_10_1128_mSystems_00283_20 crossref_primary_10_1080_21505594_2017_1385692 crossref_primary_10_1111_mmi_14565 crossref_primary_10_1128_mSphere_00023_18 crossref_primary_10_1002_wrna_1424 crossref_primary_10_1101_gr_218727_116 crossref_primary_10_3390_jof5020052 crossref_primary_10_3390_ijms222212390 crossref_primary_10_1139_cjm_2020_0239 crossref_primary_10_3389_fmicb_2016_00708 crossref_primary_10_1371_journal_ppat_1006051 crossref_primary_10_1038_s41598_023_41281_4 crossref_primary_10_1080_20002297_2024_2307067 crossref_primary_10_1007_s00253_022_12025_7 crossref_primary_10_1111_nph_19798 crossref_primary_10_1002_cpmc_94 crossref_primary_10_3389_fcimb_2021_774340 crossref_primary_10_1371_journal_ppat_1007945 crossref_primary_10_1128_mBio_01872_17 crossref_primary_10_3390_jof7121016 crossref_primary_10_1128_mBio_02313_21 crossref_primary_10_1016_j_biochi_2018_05_007 crossref_primary_10_1093_femsml_uqac015 crossref_primary_10_1111_mmi_13960 crossref_primary_10_1128_mbio_03384_22 crossref_primary_10_1128_mBio_01020_20 crossref_primary_10_1128_mBio_01862_15 crossref_primary_10_2174_1389203720666190715145131 crossref_primary_10_1111_nyas_13739 |
Cites_doi | 10.1016/S1369-5274(00)00103-X 10.1101/gad.11.23.3206 10.1126/science.1103773 10.1021/bi9618676 10.1099/mic.0.032854-0 10.1016/S0882-4010(02)00195-X 10.1128/mBio.00007-12 10.1164/rccm.201403-0431OC 10.1111/mmi.12065 10.1111/j.1462-5822.2012.01819.x 10.1371/journal.ppat.1000776 10.3389/fmicb.2014.00549 10.1099/00221287-143-2-367 10.1111/myc.12097 10.1111/j.1365-2958.2011.07632.x 10.1016/j.cll.2013.03.009 10.1111/j.1365-2958.2008.06374.x 10.1371/journal.ppat.0030042 10.1038/nrmicro2688 10.1002/jobm.200610143 10.1111/j.1365-2958.2006.05436.x 10.1021/pr901063t 10.1006/fgbi.1999.1118 10.1371/journal.pone.0016076 10.1038/nbt.2839 10.1128/IAI.01037-12 10.1091/mbc.11.2.663 10.1021/ac026117i 10.1371/journal.pone.0011113 10.1021/ac102179j 10.1097/QAD.0b013e328322ffac 10.1038/ncomms6550 10.1128/IAI.36.3.1175-1184.1982 10.1128/9781555818241 10.1146/annurev.micro.62.081307.162753 10.1128/IAI.67.11.6034-6039.1999 10.1198/jcgs.2009.07098 10.1128/JB.94.5.1475-1479.1967 10.1128/IAI.51.1.218-223.1986 10.1091/mbc.E06-08-0701 10.1128/IAI.01421-12 10.1042/BST0350284 10.1128/EC.00111-14 10.1128/MCB.01359-13 10.1016/j.cell.2008.07.046 10.1128/MCB.14.7.4912 10.1002/pmic.200800297 10.1111/j.1365-2958.2008.06588.x 10.1111/j.1567-1364.2006.00105.x 10.1128/CMR.8.4.515 10.1373/clinchem.2009.138420 10.1128/JB.131.2.702-706.1977 10.1128/IAI.00507-12 10.1093/bioinformatics/bti610 10.1007/s00438-004-1085-6 10.1128/CDLI.3.5.570-574.1996 10.1093/database/bar001 10.1111/j.1567-1364.2006.00198.x 10.1128/EC.00399-06 10.1093/infdis/jit029 10.1021/pr1011697 10.1128/JB.150.3.1414-1421.1982 10.1128/CMR.13.1.122-143.2000 10.1093/bioinformatics/btq054 10.1128/EC.3.1.14-26.2004 10.1016/S1570-0232(02)00914-5 10.1111/j.1462-5822.2008.01273.x 10.1093/nar/gks1262 10.1111/j.1365-2958.2004.04474.x 10.1002/elps.200410262 10.1155/2011/282739 10.1016/j.fgb.2013.08.005 10.1128/IAI.01607-14 10.1128/EC.00128-12 10.1128/MCB.21.9.3179-3191.2001 10.1038/nrmicro2522 10.1111/j.1365-2958.2012.08134.x 10.1111/j.1567-1364.2006.00043.x 10.1073/pnas.0631608100 10.1128/EC.00370-07 10.1042/bj3180989 10.1128/EC.00318-06 10.1074/mcp.T500030-MCP200 10.1093/bioinformatics/18.4.585 10.1128/MCB.14.3.1920 10.1128/mBio.00103-11 10.1016/j.tim.2008.12.005 10.1016/j.chom.2011.02.003 10.1002/elps.1150070108 10.1046/j.1365-2958.2001.02236.x |
ContentType | Journal Article |
Copyright | COPYRIGHT 2015 BioMed Central Ltd. Copyright BioMed Central 2015 Geddes et al. 2015 |
Copyright_xml | – notice: COPYRIGHT 2015 BioMed Central Ltd. – notice: Copyright BioMed Central 2015 – notice: Geddes et al. 2015 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION ISR 3V. 7QL 7T7 7U9 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
DOI | 10.1186/s12866-015-0532-3 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Industrial and Applied Microbiology Abstracts (Microbiology A) Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Collection AIDS and Cancer Research Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1471-2180 |
EndPage | 206 |
ExternalDocumentID | 4017127481 A541371935 10_1186_s12866_015_0532_3 26453029 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -A0 0R~ 23N 2WC 3V. 4.4 53G 5VS 6J9 7X7 88E 8FE 8FH 8FI 8FJ A8Z AAFWJ AAJSJ ABDBF ABUWG ACGFO ACGFS ACIHN ACPRK ACRMQ ADBBV ADINQ ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AFRAH AGJBV AHBYD AHMBA AHSBF AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BHPHI BMC BPHCQ BVXVI C24 C6C CCPQU CGR CS3 CUY CVF DIK DU5 E3Z EAD EAP EAS EBD EBLON EBS ECM EIF EJD EMB EMK EMOBN ESTFP ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HCIFZ HMCUK HYE IAO IGS IHR INH INR ISR ITC KQ8 LK5 LK8 M1P M48 M7P M7R MM. M~E NPM O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC PSQYO RBZ RNS ROL RPM RSV SBL SOJ SV3 TR2 TUS UKHRP W2D WOQ WOW XSB ~02 AAYXX CITATION AFGXO 7QL 7T7 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PQEST PQUKI PRINS 7X8 5PM |
ID | FETCH-LOGICAL-c528t-7a22eb7f8e6447dbc0b86741e12ff9c41b981ebadea59f5ed6c4aec47375f7713 |
IEDL.DBID | RPM |
ISSN | 1471-2180 |
IngestDate | Tue Sep 17 21:28:27 EDT 2024 Fri Aug 16 09:01:05 EDT 2024 Fri Sep 13 05:37:47 EDT 2024 Wed Aug 14 18:53:19 EDT 2024 Tue Aug 13 05:22:43 EDT 2024 Sat Sep 28 21:31:20 EDT 2024 Thu Sep 12 18:01:10 EDT 2024 Sat Sep 28 07:57:17 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c528t-7a22eb7f8e6447dbc0b86741e12ff9c41b981ebadea59f5ed6c4aec47375f7713 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600298/ |
PMID | 26453029 |
PQID | 1779840698 |
PQPubID | 42585 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4600298 proquest_miscellaneous_1722186969 proquest_journals_1779840698 gale_infotracmisc_A541371935 gale_infotracacademiconefile_A541371935 gale_incontextgauss_ISR_A541371935 crossref_primary_10_1186_s12866_015_0532_3 pubmed_primary_26453029 |
PublicationCentury | 2000 |
PublicationDate | 2015-10-09 |
PublicationDateYYYYMMDD | 2015-10-09 |
PublicationDate_xml | – month: 10 year: 2015 text: 2015-10-09 day: 09 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: London |
PublicationTitle | BMC microbiology |
PublicationTitleAlternate | BMC Microbiol |
PublicationYear | 2015 |
Publisher | BioMed Central Ltd BioMed Central |
Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central |
References | 22354955 - MBio. 2012;3(1). pii: e00007-12. doi: 10.1128/mBio.00007-12 18673460 - Mol Microbiol. 2008 Sep;69(6):1456-75 21453402 - Mol Microbiol. 2011 May;80(4):1088-101 18442 - J Bacteriol. 1977 Aug;131(2):702-6 23322637 - MBio. 2013;4(1). pii: e00522-12. doi: 10.1128/mBio.00522-12 24711572 - Infect Immun. 2014 Jul;82(7):2697-712 24727771 - Nat Biotechnol. 2014 Mar;32(3):223-6 9043114 - Microbiology. 1997 Feb;143 ( Pt 2):367-76 17038119 - Mol Microbiol. 2006 Nov;62(4):970-83 19182676 - AIDS. 2009 Feb 20;23(4):525-30 24324006 - Mol Cell Biol. 2014 Feb;34(4):673-84 6057803 - J Bacteriol. 1967 Nov;94(5):1475-9 18850632 - Proteomics. 2008 Nov;8(22):4624-32 10627494 - Clin Microbiol Rev. 2000 Jan;13(1):122-43, table of contents 17367210 - PLoS Pathog. 2007 Mar;3(3):e42 12016056 - Bioinformatics. 2002 Apr;18(4):585-96 6807845 - Infect Immun. 1982 Jun;36(3):1175-84 17371261 - Biochem Soc Trans. 2007 Apr;35(Pt 2):284-7 19299133 - Trends Microbiol. 2009 Apr;17(4):158-62 23931836 - Clin Lab Med. 2013 Sep;33(3):505-25 11123698 - Mol Microbiol. 2001 Jan;39(1):166-75 10531264 - Infect Immun. 1999 Nov;67(11):6034-9 8877137 - Clin Diagn Lab Immunol. 1996 Sep;3(5):570-4 15653466 - Science. 2005 Feb 25;307(5713):1321-4 12585499 - Anal Chem. 2003 Feb 1;75(3):663-70 17139612 - J Basic Microbiol. 2006;46(6):470-9 23381992 - Infect Immun. 2013 Apr;81(4):1245-55 8665468 - Clin Microbiol Rev. 1995 Oct;8(4):515-48 21249145 - PLoS One. 2011;6(1):e16076 20174553 - PLoS Pathog. 2010 Feb;6(2):e1000776 9389652 - Genes Dev. 1997 Dec 1;11(23):3206-17 15578222 - Mol Genet Genomics. 2005 Feb;272(6):639-50 17233760 - FEMS Yeast Res. 2007 Jun;7(4):499-510 20078137 - J Proteome Res. 2010 Apr 5;9(4):1902-12 24895304 - MBio. 2014;5(3):e01101-14 11287622 - Mol Cell Biol. 2001 May;21(9):3179-91 8114723 - Mol Cell Biol. 1994 Mar;14(3):1920-8 8007987 - Mol Cell Biol. 1994 Jul;14(7):4912-9 17021252 - Mol Biol Cell. 2006 Dec;17(12):5131-40 20022980 - Clin Chem. 2010 Feb;56(2):291-305 25368609 - Front Microbiol. 2014 Oct 20;5:549 19170685 - Cell Microbiol. 2009 Mar;11(3):370-80 21652778 - MBio. 2011;2(3):e00103-11 21291285 - J Proteome Res. 2011 Apr 1;10(4):1929-43 16081474 - Bioinformatics. 2005 Sep 15;21(18):3674-6 21090646 - Anal Chem. 2010 Dec 15;82(24):10116-24 15720553 - Mol Microbiol. 2005 Mar;55(5):1452-72 25417972 - Nat Commun. 2014;5:5550 20559436 - PLoS One. 2010;5(6):e11113 24906412 - Eukaryot Cell. 2014 Dec;13(12):1484-93 21922037 - Oxid Med Cell Longev. 2011;2011:282739 19729402 - Microbiology. 2009 Dec;155(Pt 12):3860-7 22080930 - Nat Rev Microbiol. 2012 Jan;10(1):27-38 21300622 - Database (Oxford). 2011;2011:bar001 23322859 - J Infect Dis. 2013 Apr 15;207(8):1339-47 23954835 - Fungal Genet Biol. 2013 Nov;60:53-63 23203882 - Nucleic Acids Res. 2013 Jan;41(Database issue):D1063-9 22707485 - Eukaryot Cell. 2012 Aug;11(8):1042-54 19575556 - Annu Rev Microbiol. 2009;63:223-47 23132495 - Infect Immun. 2013 Jan;81(1):292-302 10328981 - Fungal Genet Biol. 1999 Mar;26(2):99-117 14871933 - Eukaryot Cell. 2004 Feb;3(1):14-26 19210702 - Mol Microbiol. 2009 Mar;71(5):1165-76 17400891 - Eukaryot Cell. 2007 May;6(5):855-67 17114598 - Eukaryot Cell. 2007 Jan;6(1):48-59 20147306 - Bioinformatics. 2010 Apr 1;26(7):966-8 6804444 - J Bacteriol. 1982 Jun;150(3):1414-21 12623274 - Microb Pathog. 2003 Feb;34(2):65-71 22717009 - Mol Microbiol. 2012 Aug;85(4):700-15 25227465 - MBio. 2014;5(5):e01649-14 22646320 - Cell Microbiol. 2012 Oct;14(10):1544-53 23078142 - Mol Microbiol. 2012 Dec;86(6):1404-23 9100023 - Biochemistry. 1997 Apr 8;36(14):4278-86 8836148 - Biochem J. 1996 Sep 15;318 ( Pt 3):989-96 17042750 - FEMS Yeast Res. 2006 Nov;6(7):1010-7 15895463 - Electrophoresis. 2005 Jun;26(12):2481-9 10972493 - Curr Opin Microbiol. 2000 Aug;3(4):354-8 21402362 - Cell Host Microbe. 2011 Mar 17;9(3):243-51 16696661 - FEMS Yeast Res. 2006 Jun;6(4):645-51 18854164 - Cell. 2008 Oct 3;135(1):174-88 18039940 - Eukaryot Cell. 2008 Jan;7(1):58-67 10679022 - Mol Biol Cell. 2000 Feb;11(2):663-76 12554139 - J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Mar 5;785(2):263-75 12724530 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):5813-8 3079732 - Infect Immun. 1986 Jan;51(1):218-23 25007380 - Am J Respir Crit Care Med. 2014 Aug 1;190(3):309-17 21326274 - Nat Rev Microbiol. 2011 Mar;9(3):193-203 22890995 - Infect Immun. 2012 Nov;80(11):3776-85 16249172 - Mol Cell Proteomics. 2005 Dec;4(12):2010-21 3141580 - J Gen Microbiol. 1988 Apr;134(4):1037-41 A Yoneda (532_CR38) 2006; 17 M Dickman (532_CR65) 1999; 26 P Kirkham (532_CR76) 2007; 35 M Rodrigues (532_CR15) 2003; 34 C Damerval (532_CR79) 1986; 7 B Cadieux (532_CR44) 2013; 207 L Kozubowski (532_CR18) 2009; 11 SE Abbatiello (532_CR33) 2010; 56 LJ Foster (532_CR80) 2003; 100 B MacLean (532_CR92) 2010; 82 PJ Boersema (532_CR83) 2008; 8 JA Alspaugh (532_CR16) 1997; 11 KA McDonough (532_CR20) 2012; 10 S Lev (532_CR27) 2013; 81 KJ Kwon-Chung (532_CR6) 1986; 51 M Chayakulkeeree (532_CR26) 2011; 80 A Conesa (532_CR85) 2005; 21 JM Wolf (532_CR39) 2014; 13 DL Oliveira (532_CR72) 2010; 5 G Hu (532_CR89) 2008; 69 M Kretschmer (532_CR68) 2014; 82 BJ Park (532_CR2) 2009; 23 I Collopy-Junior (532_CR67) 2006; 6 L Liu (532_CR54) 1999; 67 OW Liu (532_CR58) 2008; 135 MA Ghannoum (532_CR10) 2000; 13 JW Kronstad (532_CR19) 2011; 9 AN Schuetz (532_CR74) 2013; 33 I Polacheck (532_CR7) 1988; 134 T Sun (532_CR36) 2014; 5 CD Chun (532_CR59) 2011; 9 532_CR32 C Biondo (532_CR49) 2006; 6 JA Vizcaíno (532_CR93) 2014; 30 L Chen (532_CR13) 1996; 3 C Polson (532_CR90) 2003; 785 D Macekova (532_CR50) 2006; 46 D Greenbaum (532_CR63) 2002; 18 G Hu (532_CR37) 2013; 81 H Iefuji (532_CR60) 1996; 318 G Cox (532_CR11) 2001; 39 532_CR73 T Lian (532_CR43) 2005; 55 Y Fang (532_CR81) 2010; 9 X Zhan (532_CR66) 2000; 11 G Chen (532_CR64) 1997; 36 K Vu (532_CR14) 2014; 5 ML Rodrigues (532_CR23) 2007; 6 M Zellner (532_CR30) 2005; 26 CP Silveira (532_CR42) 2013; 60 C Klein (532_CR40) 1994; 14 TL Doering (532_CR70) 2009; 63 MS Price (532_CR41) 2011; 2 JK Hicks (532_CR21) 2004; 3 J Crabtree (532_CR35) 2012; 80 GS Bulmer (532_CR3) 1967; 94 ED Holbrook (532_CR48) 2011; 10 G Janbon (532_CR86) 2014; 57 A Casadevall (532_CR9) 1998 TR O’Meara (532_CR46) 2013; 4 G Hu (532_CR22) 2007; 3 K Affolter (532_CR75) 2014; 190 CL Marion (532_CR78) 2006; 62 TR O’Meara (532_CR45) 2010; 6 P Ngamskulrungroj (532_CR62) 2011; 6 LG Baker (532_CR56) 2007; 6 KJ Kwon-Chung (532_CR4) 1982; 150 B MacLean (532_CR91) 2010; 26 JA Vizcaino (532_CR94) 2013; 41 JC Rhodes (532_CR5) 1982; 36 TR O’Meara (532_CR47) 2014; 34 S Lev (532_CR28) 2014; 5 B Loftus (532_CR31) 2005; 307 M Kretschmer (532_CR34) 2012; 11 TG Mitchell (532_CR1) 1995; 8 J Panepinto (532_CR25) 2009; 71 A Casadevall (532_CR69) 2009; 17 HC Eisenman (532_CR71) 2009; 155 R Maruvada (532_CR12) 2012; 14 A Casadevall (532_CR55) 2000; 3 H Wickham (532_CR87) 2010; 19 A Sarthy (532_CR53) 1997; 143 J Choi (532_CR29) 2012; 85 RA Eigenheer (532_CR51) 2007; 7 EJ Griffiths (532_CR88) 2012; 86 J Rappsilber (532_CR82) 2003; 75 B Leuthner (532_CR61) 2005; 272 M Meyer (532_CR52) 1977; 131 ML Rodrigues (532_CR24) 2008; 7 NM Gilbert (532_CR57) 2012; 3 YC Chang (532_CR8) 1994; 14 I Perrotta (532_CR77) 2011; 2011 J Olsen (532_CR84) 2005; 4 CA D’Souza (532_CR17) 2001; 21 |
References_xml | – volume: 3 start-page: 354 issue: 4 year: 2000 ident: 532_CR55 publication-title: Curr Opin Microbiol doi: 10.1016/S1369-5274(00)00103-X contributor: fullname: A Casadevall – volume: 11 start-page: 3206 issue: 23 year: 1997 ident: 532_CR16 publication-title: Genes Dev doi: 10.1101/gad.11.23.3206 contributor: fullname: JA Alspaugh – volume: 307 start-page: 1321 issue: 5713 year: 2005 ident: 532_CR31 publication-title: Science doi: 10.1126/science.1103773 contributor: fullname: B Loftus – volume: 36 start-page: 4278 issue: 14 year: 1997 ident: 532_CR64 publication-title: Biochemistry doi: 10.1021/bi9618676 contributor: fullname: G Chen – volume: 155 start-page: 3860 year: 2009 ident: 532_CR71 publication-title: Microbiology-Sgm doi: 10.1099/mic.0.032854-0 contributor: fullname: HC Eisenman – volume: 34 start-page: 65 issue: 2 year: 2003 ident: 532_CR15 publication-title: Microb Pathog doi: 10.1016/S0882-4010(02)00195-X contributor: fullname: M Rodrigues – volume: 3 start-page: e00007 issue: 1 year: 2012 ident: 532_CR57 publication-title: Mbio doi: 10.1128/mBio.00007-12 contributor: fullname: NM Gilbert – volume: 190 start-page: 309 issue: 3 year: 2014 ident: 532_CR75 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201403-0431OC contributor: fullname: K Affolter – volume: 86 start-page: 1404 issue: 6 year: 2012 ident: 532_CR88 publication-title: Mol Microbiol doi: 10.1111/mmi.12065 contributor: fullname: EJ Griffiths – volume: 14 start-page: 1544 issue: 10 year: 2012 ident: 532_CR12 publication-title: Cell Microbiol doi: 10.1111/j.1462-5822.2012.01819.x contributor: fullname: R Maruvada – volume: 6 start-page: e1000776 issue: 2 year: 2010 ident: 532_CR45 publication-title: PLos Pathogens doi: 10.1371/journal.ppat.1000776 contributor: fullname: TR O’Meara – ident: 532_CR73 doi: 10.3389/fmicb.2014.00549 – volume: 4 start-page: e00522 issue: 1 year: 2013 ident: 532_CR46 publication-title: Mbio contributor: fullname: TR O’Meara – volume: 143 start-page: 367 year: 1997 ident: 532_CR53 publication-title: Microbiology-Uk doi: 10.1099/00221287-143-2-367 contributor: fullname: A Sarthy – volume: 57 start-page: 27 year: 2014 ident: 532_CR86 publication-title: Mycoses doi: 10.1111/myc.12097 contributor: fullname: G Janbon – volume: 80 start-page: 1088 issue: 4 year: 2011 ident: 532_CR26 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2011.07632.x contributor: fullname: M Chayakulkeeree – volume: 33 start-page: 505 issue: 3 year: 2013 ident: 532_CR74 publication-title: Clin Lab Med doi: 10.1016/j.cll.2013.03.009 contributor: fullname: AN Schuetz – volume: 69 start-page: 1456 issue: 6 year: 2008 ident: 532_CR89 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2008.06374.x contributor: fullname: G Hu – volume: 3 start-page: e42 issue: 3 year: 2007 ident: 532_CR22 publication-title: PLoS Pathog doi: 10.1371/journal.ppat.0030042 contributor: fullname: G Hu – volume: 10 start-page: 27 issue: 1 year: 2012 ident: 532_CR20 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2688 contributor: fullname: KA McDonough – volume: 46 start-page: 470 issue: 6 year: 2006 ident: 532_CR50 publication-title: J Basic Microbiol doi: 10.1002/jobm.200610143 contributor: fullname: D Macekova – volume: 62 start-page: 970 issue: 4 year: 2006 ident: 532_CR78 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2006.05436.x contributor: fullname: CL Marion – volume: 9 start-page: 1902 issue: 4 year: 2010 ident: 532_CR81 publication-title: J Proteome Res doi: 10.1021/pr901063t contributor: fullname: Y Fang – volume: 26 start-page: 99 issue: 2 year: 1999 ident: 532_CR65 publication-title: Fungal Genet Biol doi: 10.1006/fgbi.1999.1118 contributor: fullname: M Dickman – volume: 6 start-page: e16076 issue: 1 year: 2011 ident: 532_CR62 publication-title: PLos One doi: 10.1371/journal.pone.0016076 contributor: fullname: P Ngamskulrungroj – volume: 30 start-page: 223 issue: 3 year: 2014 ident: 532_CR93 publication-title: Nat Biotechnol doi: 10.1038/nbt.2839 contributor: fullname: JA Vizcaíno – volume: 81 start-page: 292 issue: 1 year: 2013 ident: 532_CR37 publication-title: Infect Immun doi: 10.1128/IAI.01037-12 contributor: fullname: G Hu – volume: 11 start-page: 663 issue: 2 year: 2000 ident: 532_CR66 publication-title: Mol Biol Cell doi: 10.1091/mbc.11.2.663 contributor: fullname: X Zhan – volume: 75 start-page: 663 issue: 3 year: 2003 ident: 532_CR82 publication-title: Anal Chem doi: 10.1021/ac026117i contributor: fullname: J Rappsilber – volume: 5 start-page: e11113 issue: 6 year: 2010 ident: 532_CR72 publication-title: PLos One doi: 10.1371/journal.pone.0011113 contributor: fullname: DL Oliveira – volume: 82 start-page: 10116 issue: 24 year: 2010 ident: 532_CR92 publication-title: Anal Chem doi: 10.1021/ac102179j contributor: fullname: B MacLean – volume: 23 start-page: 525 issue: 4 year: 2009 ident: 532_CR2 publication-title: AIDS doi: 10.1097/QAD.0b013e328322ffac contributor: fullname: BJ Park – volume: 5 start-page: 5550 year: 2014 ident: 532_CR36 publication-title: Nat Commun doi: 10.1038/ncomms6550 contributor: fullname: T Sun – volume: 5 start-page: e01649 issue: 5 year: 2014 ident: 532_CR28 publication-title: Mbio contributor: fullname: S Lev – volume: 36 start-page: 1175 issue: 3 year: 1982 ident: 532_CR5 publication-title: Infect Immun doi: 10.1128/IAI.36.3.1175-1184.1982 contributor: fullname: JC Rhodes – volume-title: Cryptococcus neoformans: Washington year: 1998 ident: 532_CR9 doi: 10.1128/9781555818241 contributor: fullname: A Casadevall – volume: 63 start-page: 223 year: 2009 ident: 532_CR70 publication-title: Annu Rev Microbiol doi: 10.1146/annurev.micro.62.081307.162753 contributor: fullname: TL Doering – volume: 134 start-page: 1037 issue: 4 year: 1988 ident: 532_CR7 publication-title: J Gen Microbiol contributor: fullname: I Polacheck – volume: 67 start-page: 6034 issue: 11 year: 1999 ident: 532_CR54 publication-title: Infect Immun doi: 10.1128/IAI.67.11.6034-6039.1999 contributor: fullname: L Liu – volume: 19 start-page: 3 issue: 1 year: 2010 ident: 532_CR87 publication-title: J Comput Graph Stat doi: 10.1198/jcgs.2009.07098 contributor: fullname: H Wickham – volume: 94 start-page: 1475 issue: 5 year: 1967 ident: 532_CR3 publication-title: J Bacteriol doi: 10.1128/JB.94.5.1475-1479.1967 contributor: fullname: GS Bulmer – volume: 51 start-page: 218 issue: 1 year: 1986 ident: 532_CR6 publication-title: Infect Immun doi: 10.1128/IAI.51.1.218-223.1986 contributor: fullname: KJ Kwon-Chung – volume: 17 start-page: 5131 issue: 12 year: 2006 ident: 532_CR38 publication-title: Mol Biol Cell doi: 10.1091/mbc.E06-08-0701 contributor: fullname: A Yoneda – volume: 81 start-page: 1245 issue: 4 year: 2013 ident: 532_CR27 publication-title: Infect Immun doi: 10.1128/IAI.01421-12 contributor: fullname: S Lev – volume: 35 start-page: 284 year: 2007 ident: 532_CR76 publication-title: Biochem Soc Trans doi: 10.1042/BST0350284 contributor: fullname: P Kirkham – volume: 13 start-page: 1484 issue: 12 year: 2014 ident: 532_CR39 publication-title: Eukaryotic Cell doi: 10.1128/EC.00111-14 contributor: fullname: JM Wolf – volume: 34 start-page: 673 issue: 4 year: 2014 ident: 532_CR47 publication-title: Mol Cell Biol doi: 10.1128/MCB.01359-13 contributor: fullname: TR O’Meara – volume: 135 start-page: 174 issue: 1 year: 2008 ident: 532_CR58 publication-title: Cell doi: 10.1016/j.cell.2008.07.046 contributor: fullname: OW Liu – volume: 14 start-page: 4912 issue: 7 year: 1994 ident: 532_CR8 publication-title: Mol Cell Biol doi: 10.1128/MCB.14.7.4912 contributor: fullname: YC Chang – volume: 8 start-page: 4624 issue: 22 year: 2008 ident: 532_CR83 publication-title: Proteomics doi: 10.1002/pmic.200800297 contributor: fullname: PJ Boersema – volume: 71 start-page: 1165 issue: 5 year: 2009 ident: 532_CR25 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2008.06588.x contributor: fullname: J Panepinto – volume: 6 start-page: 1010 issue: 7 year: 2006 ident: 532_CR67 publication-title: Fems Yeast Res doi: 10.1111/j.1567-1364.2006.00105.x contributor: fullname: I Collopy-Junior – volume: 8 start-page: 515 issue: 4 year: 1995 ident: 532_CR1 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.8.4.515 contributor: fullname: TG Mitchell – volume: 56 start-page: 291 issue: 2 year: 2010 ident: 532_CR33 publication-title: Clin Chem doi: 10.1373/clinchem.2009.138420 contributor: fullname: SE Abbatiello – volume: 131 start-page: 702 issue: 2 year: 1977 ident: 532_CR52 publication-title: J Bacteriol doi: 10.1128/JB.131.2.702-706.1977 contributor: fullname: M Meyer – volume: 80 start-page: 3776 issue: 11 year: 2012 ident: 532_CR35 publication-title: Infect Immun doi: 10.1128/IAI.00507-12 contributor: fullname: J Crabtree – volume: 21 start-page: 3674 issue: 18 year: 2005 ident: 532_CR85 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti610 contributor: fullname: A Conesa – volume: 272 start-page: 639 issue: 6 year: 2005 ident: 532_CR61 publication-title: Mol Gen Genomics doi: 10.1007/s00438-004-1085-6 contributor: fullname: B Leuthner – volume: 3 start-page: 570 issue: 5 year: 1996 ident: 532_CR13 publication-title: Clin Diagn Lab Immunol doi: 10.1128/CDLI.3.5.570-574.1996 contributor: fullname: L Chen – ident: 532_CR32 doi: 10.1093/database/bar001 – volume: 7 start-page: 499 issue: 4 year: 2007 ident: 532_CR51 publication-title: Fems Yeast Res doi: 10.1111/j.1567-1364.2006.00198.x contributor: fullname: RA Eigenheer – volume: 6 start-page: 855 issue: 5 year: 2007 ident: 532_CR56 publication-title: Eukaryotic Cell doi: 10.1128/EC.00399-06 contributor: fullname: LG Baker – volume: 207 start-page: 1339 issue: 8 year: 2013 ident: 532_CR44 publication-title: J Infect Dis doi: 10.1093/infdis/jit029 contributor: fullname: B Cadieux – volume: 10 start-page: 1929 issue: 4 year: 2011 ident: 532_CR48 publication-title: J Proteome Res doi: 10.1021/pr1011697 contributor: fullname: ED Holbrook – volume: 150 start-page: 1414 issue: 3 year: 1982 ident: 532_CR4 publication-title: J Bacteriol doi: 10.1128/JB.150.3.1414-1421.1982 contributor: fullname: KJ Kwon-Chung – volume: 13 start-page: 122 issue: 1 year: 2000 ident: 532_CR10 publication-title: Clin Microbiol Rev doi: 10.1128/CMR.13.1.122-143.2000 contributor: fullname: MA Ghannoum – volume: 26 start-page: 966 issue: 7 year: 2010 ident: 532_CR91 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq054 contributor: fullname: B MacLean – volume: 5 start-page: e01101 issue: 3 year: 2014 ident: 532_CR14 publication-title: Mbio contributor: fullname: K Vu – volume: 3 start-page: 14 issue: 1 year: 2004 ident: 532_CR21 publication-title: Eukaryot Cell doi: 10.1128/EC.3.1.14-26.2004 contributor: fullname: JK Hicks – volume: 785 start-page: 263 issue: 2 year: 2003 ident: 532_CR90 publication-title: J Chromatogr B Analyt Technol Biomed Life Sci doi: 10.1016/S1570-0232(02)00914-5 contributor: fullname: C Polson – volume: 11 start-page: 370 issue: 3 year: 2009 ident: 532_CR18 publication-title: Cell Microbiol doi: 10.1111/j.1462-5822.2008.01273.x contributor: fullname: L Kozubowski – volume: 41 start-page: D1063 issue: D1 year: 2013 ident: 532_CR94 publication-title: Nucleic Acids Res doi: 10.1093/nar/gks1262 contributor: fullname: JA Vizcaino – volume: 55 start-page: 1452 issue: 5 year: 2005 ident: 532_CR43 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2004.04474.x contributor: fullname: T Lian – volume: 26 start-page: 2481 issue: 12 year: 2005 ident: 532_CR30 publication-title: Electrophoresis doi: 10.1002/elps.200410262 contributor: fullname: M Zellner – volume: 2011 start-page: 282739 year: 2011 ident: 532_CR77 publication-title: Oxidative Med Cell Longev doi: 10.1155/2011/282739 contributor: fullname: I Perrotta – volume: 60 start-page: 53 year: 2013 ident: 532_CR42 publication-title: Fungal Genet Biol doi: 10.1016/j.fgb.2013.08.005 contributor: fullname: CP Silveira – volume: 82 start-page: 2697 issue: 7 year: 2014 ident: 532_CR68 publication-title: Infect Immun doi: 10.1128/IAI.01607-14 contributor: fullname: M Kretschmer – volume: 11 start-page: 1042 issue: 8 year: 2012 ident: 532_CR34 publication-title: Eukaryotic Cell doi: 10.1128/EC.00128-12 contributor: fullname: M Kretschmer – volume: 21 start-page: 3179 issue: 9 year: 2001 ident: 532_CR17 publication-title: Mol Cell Biol doi: 10.1128/MCB.21.9.3179-3191.2001 contributor: fullname: CA D’Souza – volume: 9 start-page: 193 issue: 3 year: 2011 ident: 532_CR19 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro2522 contributor: fullname: JW Kronstad – volume: 85 start-page: 700 issue: 4 year: 2012 ident: 532_CR29 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2012.08134.x contributor: fullname: J Choi – volume: 6 start-page: 645 issue: 4 year: 2006 ident: 532_CR49 publication-title: Fems Yeast Res doi: 10.1111/j.1567-1364.2006.00043.x contributor: fullname: C Biondo – volume: 100 start-page: 5813 issue: 10 year: 2003 ident: 532_CR80 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0631608100 contributor: fullname: LJ Foster – volume: 7 start-page: 58 issue: 1 year: 2008 ident: 532_CR24 publication-title: Eukaryotic Cell doi: 10.1128/EC.00370-07 contributor: fullname: ML Rodrigues – volume: 318 start-page: 989 year: 1996 ident: 532_CR60 publication-title: Biochem J doi: 10.1042/bj3180989 contributor: fullname: H Iefuji – volume: 6 start-page: 48 issue: 1 year: 2007 ident: 532_CR23 publication-title: Eukaryotic Cell doi: 10.1128/EC.00318-06 contributor: fullname: ML Rodrigues – volume: 4 start-page: 2010 issue: 12 year: 2005 ident: 532_CR84 publication-title: Mol Cell Proteomics doi: 10.1074/mcp.T500030-MCP200 contributor: fullname: J Olsen – volume: 18 start-page: 585 issue: 4 year: 2002 ident: 532_CR63 publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.4.585 contributor: fullname: D Greenbaum – volume: 14 start-page: 1920 issue: 3 year: 1994 ident: 532_CR40 publication-title: Mol Cell Biol doi: 10.1128/MCB.14.3.1920 contributor: fullname: C Klein – volume: 2 start-page: e00103 issue: 3 year: 2011 ident: 532_CR41 publication-title: Mbio doi: 10.1128/mBio.00103-11 contributor: fullname: MS Price – volume: 17 start-page: 158 issue: 4 year: 2009 ident: 532_CR69 publication-title: Trends Microbiol doi: 10.1016/j.tim.2008.12.005 contributor: fullname: A Casadevall – volume: 9 start-page: 243 issue: 3 year: 2011 ident: 532_CR59 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2011.02.003 contributor: fullname: CD Chun – volume: 7 start-page: 52 year: 1986 ident: 532_CR79 publication-title: Electrophoresis doi: 10.1002/elps.1150070108 contributor: fullname: C Damerval – volume: 39 start-page: 166 issue: 1 year: 2001 ident: 532_CR11 publication-title: Mol Microbiol doi: 10.1046/j.1365-2958.2001.02236.x contributor: fullname: G Cox |
SSID | ssj0017837 |
Score | 2.3417606 |
Snippet | The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase... Background The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The... BACKGROUNDThe pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The... |
SourceID | pubmedcentral proquest gale crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 206 |
SubjectTerms | Analysis Animals Biological markers Biomarkers Biomarkers - analysis Cellular signal transduction Chemical Precipitation Chromatography, Liquid Cryptococcus neoformans - chemistry Culture Media - chemistry Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Enzymes Female Fungal Proteins - secretion Genes Glucose Influence Kinases Macrophages Macrophages - microbiology Metabolism Mice, Inbred BALB C Proteins Proteome - analysis Proteomics Signal transduction Tandem Mass Spectrometry Virulence Virulence (Microbiology) Virulence Factors - metabolism |
SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Li9RAEG7WFcGL-Da6SiuCIIRJOp105yTD4jIKenBdmFvTz91BTcZJIsxv8c9alce48eBpMnQFEqq66qt0VX2EvJZG24y5LM5MImKecvCDRkDWmmgeTLDW9OMYPn0uVhf84zpfH5HV1AuDZZWTT-wdtastfiNfpEKUEts05UIb_Apg28W77c8Y-aPwnHUk07hBbqYMYAVYtlgfUq9UQB42nmmmslg04JULzKTzGJkR4mwWlf71zdeC07xw8lokOrtL7owQki4Hnd8jR766T24NpJL7B-T3OSLBtv7h6UDIDcGJ1oGe7vbbtgb_Z7uGVr4e-gUaijOcwAbh93Kk8kJpTRtwKb7F61-bXdf3JsV6VKZ3tB_wsIH7dQV_4LoCX_GdYjs_VvzsGmr2kxD9tqkgWtLlQ3Jx9v7r6SoeKRhimzPZxkIz5o0I0gNuEs7YxMgCQIhPWQil5akpZeqNdl7nZci9KyzX3nKRiTwISIAfkeOqrvwTQp3JbKEBDyTccGt8yVNXOhYcc4kVRkbk7aQCtR0mbag-Q5GFGvSlQF8K9aWyiLxCJSmcYFFhicyl7ppGfTj_opY5xGUBuDSPyJtRKNRoMHrsOIDnwaFXM8mTmSRsMTtfnmxBjVu8UX8NMiIvD8t4J5atgRo7lGE951dRRuTxYDqHdwMkioxNsCJmRnUQwMHf85Vqc9UPAOf9Yap8-v_HekZuM7RwrHYoT8hxu-v8c0BQrXnRb44_zKYgcg priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bi9UwEA7riuCLePfoKlEEQai2adqkDyKHxWUV1gfXA_sWkjTZPbi2ay_i-S3-WWfS9riVffCpLZmWNDOZC5n5hpCX0mibsjKNUhOLiCcc9KARELXGmnvjrTUBjuHoc3644p9OspMdMrW3GhewvTK0w35Sq-b8za8fm_ew4d-FDS_zty3o2Bzj4izCPgdReo1cZzzlKPBH_O-hgpABQhPmk0Rg2aZDzis_MTNT_yrrS9Zqnkl5yTQd3Ca3Rp-SLgchuEN2XHWX3Bi6TG7ukd_H6Bp29XdHhw7dYK1o7el-s7noalCItm9p5eqhgKClCOoEiwPX07G3F1Jr2oKOcR3e_1w3fShWivTIXVfSgPiwhvd1BQ9wX4HyOKdY348pQE1LzWYiot_WFZhPurxPVgcfvu4fRmNPhshmTHaR0Iw5I7x04EiJ0tjYyBy8Epcw7wvLE1PIxBldOp0VPnNlbrl2lotUZF5ARPyA7FZ15R4RWprU5hochJgbbo0reFIWJfMlK2MrjFyQ1xML1MUAvaFCyCJzNfBLAb8U8kulC_ICmaQQ0qLCnJlT3bet-nj8RS0zMNQCHNVsQV6NRL4Gdlk9liDAfBAFa0a5N6OEPWfnw5MsqElkVSJEIbGQGGb-fDuMb2IeG7CxRxoWmoDlxYI8HERn-2_gmmILJxgRM6HaEiAS-HykWp8FRHAeTlfl4_9ZhCfkJkM5xySIYo_sdk3vnoJj1ZlnYbv8AeQvI3A priority: 102 providerName: Scholars Portal |
Title | Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A |
URI | https://www.ncbi.nlm.nih.gov/pubmed/26453029 https://www.proquest.com/docview/1779840698/abstract/ https://search.proquest.com/docview/1722186969 https://pubmed.ncbi.nlm.nih.gov/PMC4600298 |
Volume | 15 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3batswVLQdg72M3eetC9oYDAZufJEt-TENLd0gpaQrhL0ISZbbsMYOsTPIt-xnd45sh3qPe5FldAQy526dCyGfhVYmjvLYj3XAfRYykIOag9caKFbowhjtyjHMLtOLG_Z9kSwOSNLnwrigfaOXJ-X96qRc3rnYyvXKjPs4sfHVbMrcZZIYH5JDHse9i95dHXBwubrry1Ck4xoEcIpOc-JjEwQfG-eAEYDNcrKBLvpXIj9QScNwyQf65_wZedoZjnTSHvA5ObDlC_K4bSW5e0n-XKP911QrS9s23KCSaFXQ6Wa3biqQemZb09JWbZZATbFyE1AePG-7Bl4IrWgNgsQ2OP-93GxdRpKvOhTanLqyDkvYr0p4gXkJEuKeYhI_xvlsaqp3PRD9tSxBR9LJK3JzfvZjeuF3jRd8k0Si8bmKIqt5ISxYSzzXJtAiBdPDhlFRZIaFOhOh1Sq3KsmKxOapYcoaxmOeFBzc3tfkqKxK-5bQXMcmVWAFBEwzo23GwjzLoyKP8sBwLTzytUeBXLf1NaTzS0QqW9RJQJ1E1MnYI58QSRLrVpQYGHOrtnUtv13P5SQBbczBGk088qUDKipAl1FdngGcB0tdDSCPB5DAWGa43NOC7Bi7liHnmcBsYTj5x_0y7sRgNUDjFmEi1-krzTzypiWd_bf1pOcRPiCqPQCW-x6uABe4st8d1b_7753vyZMI-QDDH7JjctRstvYDmFSNHgEjLfiIPDo9u7yaj9yPCRhnTMA4P_05ciz2F7JpKuc |
link.rule.ids | 230,315,733,786,790,870,891,12083,21416,24346,27957,27958,31754,31755,33779,33780,43345,43840,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Zi9RAEG50FtEX8Ta6aiuCIITN0Ul3nmRcdpnV3UH2gH1r-so6qMk4SYT5Lf5Zq5KeceODT0moCiR81XV010HIW6GVSRObhqmOeMhiBnpQc4haI8VKXRqj-3YMJ_N8dsE-XWaXfsOt8WmVG53YK2pbG9wj34s5LwSWaYoPy58hTo3C01U_QuMm2WEpUCdk5-PB_Mvp9hyBQ_zlzzJjke81oI1zjKCzECcihOnIGv2rk68ZpXHC5DULdHiP3PWuI50OWN8nN1z1gNwahkmuH5LfZ-gBtvUPR4dB3GCUaF3S_dV62dag90zX0MrVQ51AQ7F3E8geXK_8CC_kVrQBVeJavP-1WHV9TVKoPIjO0r6xwwLeVxU8wH0FOuI7xTJ-zPRZNVSvN0z026ICK0mnj8jF4cH5_iz0oxdCkyWiDblKEqd5KRz4S9xqE2mRg_Ph4qQsC8NiXYjYaWWdyooyczY3TDnDeMqzkkPg-5hMqrpyTwm1OjW5Aj8gYpoZ7QoW28ImpU1sZLgWAXm_gUAuhw4bso9MRC4HvCTgJREvmQbkDYIksXNFhakxV6prGnl0diqnGdhjDv5oFpB3nqmsAS6jfKUBfA82uxpx7o44YWmZMXkjC9Iv7Ub-FcSAvN6S8U1MVwMYO-RJ-llfeRGQJ4PobP8NPFCc1AQUPhKqLQM2_B5TqsXXvvE36w9RxbP_f9Yrcnt2fnIsj4_mn5-TOwlKO2Y8FLtk0q469wK8qFa_9EvlD9PDIQs |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgCMTLuA46BhiEhISUtkmcOHmsCtUGbJoYkyZeLF9HtTWpmgSp_BX-LOfkUjV73FNT-VhylM_nIn_-DiEfEiV1GJjQC9WYe8xn4AcVh6p1LJlTTmtVyzEcn8SH5-zrRXSx1eqrJu1rNR9m14thNv9dcyuXCz3qeGKj0-Mpqw-TktHSuNFdcg_2bJB2hXp7gMCh8GoPMf0kHhXghmMsnSMPWyF42D4HUgFsmZP2ItJNv7wVmPqkya0oNHtEfnXrb8gnV8OqVEP994a0461e8DHZbXNTOmlMnpA7NntK7jfdKtfPyL8zTDHLfGFp0-kboh7NHZ2u1ssyB8eqq4JmNm8uIhQUxaEA3PB72fYIQ2tJC_BVtsTnP_NVVV968mSLEmtorRwxh_kygz_wnIETuqaoE4BUolVB1bozolfzDMIwnTwn57MvP6eHXtvbwdNRkJQel0FgFXeJhYSMG6XHKokhu7F-4Fyqma_SxLdKGiuj1EXWxJpJqxkPeeQ4VNZ7ZCfLM_uSUKNCHUtINMZMMa1synyTmsCZwIw1V8mAfOq-r1g2Eh6iLn2SWDS4EIALgbgQ4YC8RwQIlMbIkHtzKauiEEdnP8QkgoDPIeGNBuRja-RywIKW7VUGWA-qafUsD3qWsHd1f7gDmmh9RyF8ztMELyTDyt9thnEm8uHgM1ZoE9TNxOJ0QF40uNy8W4frAeE9xG4MUFG8PwI4rJXFW9zt33rmW_Lg9PNMfD86-faKPAxwvyHZIj0gO-Wqsq8hgSvVm3qr_gfl20n9 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Secretome+profiling+of+Cryptococcus+neoformans+reveals+regulation+of+a+subset+of+virulence-associated+proteins+and+potential+biomarkers+by+protein+kinase+A&rft.jtitle=BMC+microbiology&rft.au=Geddes%2C+Jennifer+M.+H&rft.au=Croll%2C+Daniel&rft.au=Caza%2C+M%C3%B1lissa&rft.au=Stoynov%2C+Nikolay&rft.date=2015-10-09&rft.pub=BioMed+Central+Ltd&rft.issn=1471-2180&rft.eissn=1471-2180&rft.volume=15&rft_id=info:doi/10.1186%2Fs12866-015-0532-3&rft.externalDBID=ISR&rft.externalDocID=A541371935 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2180&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2180&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2180&client=summon |