Phage Display Derived Monoclonal Antibodies: From Bench to Bedside

• Published in: Frontiers in immunology Vol. 11; p. 1986
• Main Authors: Alfaleh, Mohamed A., Alsaab, Hashem O., Mahmoud, Ahmad Bakur, Alkayyal, Almohanad A., Jones, Martina L., Mahler, Stephen M., Hashem, Anwar M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.08.2020
• Subjects: Animals; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; antibody libraries; Antibody Specificity - genetics; Antibody Specificity - immunology; Antineoplastic Agents, Immunological - pharmacology; Antineoplastic Agents, Immunological - therapeutic use; biopanning; biopharmaceuticals; Cell Surface Display Techniques; Clinical Trials as Topic; Drug Development - methods; Drug Evaluation, Preclinical; Genetic Engineering; High-Throughput Screening Assays; Humans; Immunology; Molecular Targeted Therapy; monoclonal antibodies; phage display; Translational Medical Research; Treatment Outcome; biopharmaceuticals; antibody libraries; biopanning; phage display; monoclonal antibodies

Monoclonal antibodies (mAbs) have become one of the most important classes of biopharmaceutical products, and they continue to dominate the universe of biopharmaceutical markets in terms of approval and sales. They are the most profitable single product class, where they represent six of the top ten...