Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress

• Published in: Cellular physiology and biochemistry Vol. 44; no. 6; pp. 2407 - 2421
• Main Authors: Cui, Yanhua, Ren, Lipeng, Li, Bo, Fang, Jia, Zhai, Yuanxin, He, Xin, Du, Enqi, Miao, Yiliang, Hua, Jinlian, Peng, Sha
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Animals; Antineoplastic Agents, Alkylating - adverse effects; Antioxidants; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Busulfan; Busulfan - adverse effects; Cancer therapies; Cell Line; Endoplasmic reticulum; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Enzymes; Experiments; Homeostasis; Insulin resistance; Kinases; Laboratory animals; Male; Melatonin; Melatonin - pharmacology; Mice; Mice, Inbred ICR; Original Paper; Oxidative stress; Proteins; Sperm; Spermatogonial stem cells; Stem cells; Testis - cytology; Testis - drug effects; Testis - pathology; Melatonin; Busulfan; Spermatogonial stem cells; Apoptosis; Endoplasmic reticulum stress

Background/Aims: Busulfan is commonly used for cancer chemotherapy. Although it has the advantage of increasing the survival rate of patients, it can cause male infertility via damaging the testes and reducing sperm counts. Therefore, the underlying mechanism should be explored, and new agents shoul...