LncRNA GAS5 Suppresses the Proliferation and Invasion of Osteosarcoma Cells via the miR-23a-3p/PTEN/PI3K/AKT Pathway

• Published in: Cell transplantation Vol. 29; p. 96368972095309
• Main Authors: Liu, Jianmin, Chen, Ming, Ma, Longyang, Dang, Xingbo, Du, Gongliang
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2020; Sage Publications Ltd; SAGE Publishing
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Bone cancer; Cell growth; Cell proliferation; Immunoprecipitation; Kinases; Metastases; Original; Osteosarcoma; Osteosarcoma cells; PTEN protein; Reporter gene; Ribonucleic acid; RNA; Sarcoma; Tensin; Tumor suppressor genes; Xenografts; long noncoding RNA; phosphatase and tensin homolog; miR-23a-3p; growth arrest special 5; osteosarcoma

Accumulating evidence has shown that long noncoding RNA GAS5 is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. However, the detailed role of GAS5 in osteosarcoma is still largely unclear. In this study, we found that GAS5 was downregulated in human osteosarcoma tiss...