Epstein–Barr virus infection and nasopharyngeal carcinoma

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 372; no. 1732; p. 20160270
• Main Authors: Tsao, Sai Wah, Tsang, Chi Man, Lo, Kwok Wai
• Format: Journal Article
• Language: English
• Published: England The Royal Society 19.10.2017; The Royal Society Publishing
• Subjects: Antigen presentation; Antigens; Cancer; Carcinoma - virology; Chromosome 6; DNA Replication; Epithelial cells; Epithelial Cells - metabolism; Epithelium; Epstein-Barr virus; Epstein-Barr Virus Infections - virology; Gene expression; Genetic transformation; Herpesvirus 4, Human - physiology; Histocompatibility antigen HLA; Human papillomavirus; Humans; Immune system; Infections; Invasiveness; Latent Epstein–barr Virus Genes; Latent infection; Mutation; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - virology; Nf-Κb Activation; NF-κB protein; Pathogenesis; Regulators; Review; Signal transduction; Signaling; Viruses; latent Epstein–Barr virus genes; NF-κB activation; nasopharyngeal carcinoma; Epstein–Barr virus

Epstein–Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chinese population. A strong association betw...