HIV-2 Neutralization Sensitivity in Relation to Co-Receptor Entry Pathways and Env Motifs

• Published in: International journal of molecular sciences Vol. 23; no. 9; p. 4766
• Main Authors: Szojka, Zsófia Ilona, Karlson, Sara, Johansson, Emil, Şahin, Gülşen Özkaya, Jansson, Marianne
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2022; MDPI
• Subjects: Acquired immune deficiency syndrome; AIDS; Amino acids; Antibodies; Asymptomatic; Basic Medicine; Env motifs; Glycoproteins; HIV; HIV-2; Human immunodeficiency virus; Immune system; Infections; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Microbiology in the Medical Area; Mikrobiologi inom det medicinska området; neutralization sensitivity; target cell co-receptors; Viruses; neutralization sensitivity; HIV-2; Env motifs; target cell co-receptors

HIV-2, compared to HIV-1, elicits potent and broadly neutralizing antibodies, and uses a broad range of co-receptors. However, both sensitivity to neutralization and breadth of co-receptor use varies between HIV-2 isolates, and the molecular background is still not fully understood. Thus, in the cur...