Antibiotics exposure and health risks: Chloramphenicol

• Published in: Environmental toxicology and pharmacology Vol. 39; no. 1; pp. 213 - 220
• Main Authors: Hanekamp, Jaap C., Bast, Aalt
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2015
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; Anti-Bacterial Agents - toxicity; Chloramphenicol (CAP); Chloramphenicol - therapeutic use; Chloramphenicol - toxicity; Dose-Response Relationship, Drug; Emergency; Food Contamination; Human nutrition; Humans; Linear non-threshold (LNT) model; Lower Limit of Detection (LOD); Maximum Residue Limit (MRL); Maximum Tolerable Risk (MTR); Minimum Required Performance Limit (MRPL); Risk Assessment; Shrimps; Threshold of Toxicological Concern (TTC); Tolerable Daily Intake (TDI); Maximum Residue Limit (MRL); Lower Limit of Detection (LOD); Shrimps; Minimum Required Performance Limit (MRPL); Threshold of Toxicological Concern (TTC); Chloramphenicol (CAP); Tolerable Daily Intake (TDI); Human nutrition; Linear non-threshold (LNT) model; Maximum Tolerable Risk (MTR)
• ISSN: 1382-6689; 1872-7077; 1872-7077
• DOI: 10.1016/j.etap.2014.11.016

•A review of the banned antibiotic chloramphenicol (CAP) in food is presented.•CAP's occurrence, sources, natural background, and risks are discussed.•Shortcomings of the toxicology of low-level exposures are reviewed.•A Threshold of Toxicological Concern (TTC) for CAP is proposed.•CAP's TTC is molecularly framed within its natural presence in foods. The antibiotic chloramphenicol (CAP) is banned from food production. Besides being a medicinal product, CAP is also a natural product, produced by Streptomyces Venezuelae. The lack of scientific data hampers setting of an Acceptable Daily Intake (ADI). Consequently, a maximum residue limit (MRL) in food could not be established. This was then translated into a zero tolerance using the so-called Minimum Required Performance Limit (MRPL) level, viz. the achievable detection limit in food, to guide the zero tolerance policy. The MRPL is clearly not relevant to food safety and human health but is solely related to analytical technological capabilities. The increase in the latter enables detection at ever-lower levels and ignores toxicological relevance. We here provide arguments to use a Threshold of Toxicological Concern (TTC) for CAP that can accommodate developing toxicological insights.