Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans - Yang, Yan; Chung, Erwin K.; Wu, Yee Ling; Savelli, Stephanie L.; Nagaraja, Haikady N.; Zhou, Bi; Hebert, Maddie; Jones, Karla N.; Shu, Yaoling; Kitzmiller, Kathryn; Blanchong, Carol A.; McBride, Kim L.; et al. (American journal of human genetics, 2007)
Keywords: Adult; Alleles; Biological and medical sciences; Case-Control Studies; Cohort Studies; Complement C4 - genetics; Disease Susceptibility; Female; Fundamental and applied biological sciences. Psychology; Gene Dosage; Gene Frequency; General aspects. Genetic counseling; Genes; Genetic research; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genetics, Population; Genomics; Haplotypes; Health risk assessment; Humans; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Male; Medical genetics; Medical sciences; Middle Aged; Minority & ethnic groups; Molecular and cellular biology; Polymorphism, Genetic; Reproducibility of Results; Risk Factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; White People - genetics; Europe; Human; Immunopathology; Connective tissue disease; High risk; Skin disease; American; Copy number; Pathogenesis; Variations; Autoimmune disease; Complement; Concentration; European; Genetic determinism; Prevention; Sensitivity; Systemic lupus erythematosus; Gene; Systemic disease; Risk factor; Predisposition; Genetics; Polymorphism