Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and...

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Published in	Frontiers in molecular neuroscience Vol. 10; p. 333
Main Authors	Ariazi, Jennifer, Benowitz, Andrew, De Biasi, Vern, Den Boer, Monique L., Cherqui, Stephanie, Cui, Haifeng, Douillet, Nathalie, Eugenin, Eliseo A., Favre, David, Goodman, Spencer, Gousset, Karine, Hanein, Dorit, Israel, David I., Kimura, Shunsuke, Kirkpatrick, Robert B., Kuhn, Nastaran, Jeong, Claire, Lou, Emil, Mailliard, Robbie, Maio, Stephen, Okafo, George, Osswald, Matthias, Pasquier, Jennifer, Polak, Roel, Pradel, Gabriele, de Rooij, Bob, Schaeffer, Peter, Skeberdis, Vytenis A., Smith, Ian F., Tanveer, Ahmad, Volkmann, Niels, Wu, Zhenhua, Zurzolo, Chiara
Format	Journal Article
Language	English
Published	Switzerland Frontiers Research Foundation 17.10.2017 Frontiers Media Frontiers Media S.A
Subjects	Age Alzheimer Biology Cancer Cell interactions Cell signaling Chemokines Communication Communications systems Cytokines Dendritic cells Disease Electrical stimuli Exosomes Gap junctions Growth factors Infections inflammation Laboratories Life Sciences Medical research Nanotubes Neuroscience Neurosciences Neurotransmitters Oncology Organelles Pediatrics reactivation Social research La Jolla California California United States > US Qatar New Jersey Germany gap junctions reactivation cancer inflammation Alzheimer
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Abstract	Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.
AbstractList	Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies. Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies. Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communications and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediates a long range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.
Author	Goodman, Spencer Den Boer, Monique L. Eugenin, Eliseo A. Kuhn, Nastaran Israel, David I. Benowitz, Andrew Favre, David Okafo, George Douillet, Nathalie Ariazi, Jennifer Hanein, Dorit de Rooij, Bob De Biasi, Vern Pradel, Gabriele Zurzolo, Chiara Pasquier, Jennifer Kimura, Shunsuke Jeong, Claire Tanveer, Ahmad Schaeffer, Peter Skeberdis, Vytenis A. Lou, Emil Polak, Roel Mailliard, Robbie Maio, Stephen Wu, Zhenhua Cui, Haifeng Cherqui, Stephanie Gousset, Karine Volkmann, Niels Kirkpatrick, Robert B. Osswald, Matthias Smith, Ian F.
AuthorAffiliation	13 GlaxoSmithKline , King of Prussia, PA , United States 16 Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg , Heidelberg , Germany 7 GlaxoSmithKline, Research Triangle Park , NC , United States 21 Department of Neurobiology and Behavior, University of California, Irvine , Irvine, CA , United States 22 Section of Intracellular Trafficking and Neurovirology, National Institute of Health , Bethesda, MD , United States 4 GlaxoSmithKline , Stevenage , United Kingdom 5 Public Health Research Institute (PHRI) , Newark, NJ , United States 9 Bioinformatics and System Biology Program, Sanford Burnham Prebys Medical Discovery , La Jolla, CA , United States 3 Division of Genetics, Department of Pediatrics, University of California, San Diego , La Jolla, CA , United States 20 Institute of Cardiology, Lithuanian University of Health Sciences , Kaunas , Lithuania 6 Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Rutgers
AuthorAffiliation_xml	– name: 4 GlaxoSmithKline , Stevenage , United Kingdom – name: 15 Department of Infectious Diseases and Microbiology, University of Pittsburgh , Pittsburgh, PA , United States – name: 2 Department of Pediatric Oncology, Erasmus MC – Sophia Children's Hospital , Rotterdam , Netherlands – name: 12 Division of Cancer Biology, Physical Sciences-Oncology Network, Cancer Tissue Engineering Collaborative Research Program, Program Director, Structural Biology and Molecular Applications Branch, National Cancer Institute , Bethesda, MD , United States – name: 9 Bioinformatics and System Biology Program, Sanford Burnham Prebys Medical Discovery , La Jolla, CA , United States – name: 11 Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University , Sapporo , Japan – name: 3 Division of Genetics, Department of Pediatrics, University of California, San Diego , La Jolla, CA , United States – name: 17 Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany – name: 19 Division of Cellular and Applied Infection Biology, RWTH Aachen University , Aachen , Germany – name: 5 Public Health Research Institute (PHRI) , Newark, NJ , United States – name: 21 Department of Neurobiology and Behavior, University of California, Irvine , Irvine, CA , United States – name: 23 Unit of Membrane Trafficking and Pathogenesis, Department of Cell Biology and Infection, Pasteur Institute , Paris , France – name: 13 GlaxoSmithKline , King of Prussia, PA , United States – name: 1 GlaxoSmithKline , Collegeville, PA , United States – name: 7 GlaxoSmithKline, Research Triangle Park , NC , United States – name: 10 GlaxoSmithKline , Waltham, MA , United States – name: 20 Institute of Cardiology, Lithuanian University of Health Sciences , Kaunas , Lithuania – name: 14 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota , Minneapolis, MN , United States – name: 6 Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Rutgers the State University of New Jersey , Newark, NJ , United States – name: 16 Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg , Heidelberg , Germany – name: 22 Section of Intracellular Trafficking and Neurovirology, National Institute of Health , Bethesda, MD , United States – name: 8 Department of Biology, College of Science and Math, California State University , Fresno, CA , United States – name: 18 Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Qatar Foundation , Ar-Rayyan , Qatar
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29089870$$D View this record in MEDLINE/PubMed https://pasteur.hal.science/pasteur-03935195$$DView record in HAL
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Copyright	2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Attribution Copyright © 2017 Ariazi, Benowitz, De Biasi, Den Boer, Cherqui, Cui, Douillet, Eugenin, Favre, Goodman, Gousset, Hanein, Israel, Kimura, Kirkpatrick, Kuhn, Jeong, Lou, Mailliard, Maio, Okafo, Osswald, Pasquier, Polak, Pradel, de Rooij, Schaeffer, Skeberdis, Smith, Tanveer, Volkmann, Wu and Zurzolo. 2017 Ariazi, Benowitz, De Biasi, Den Boer, Cherqui, Cui, Douillet, Eugenin, Favre, Goodman, Gousset, Hanein, Israel, Kimura, Kirkpatrick, Kuhn, Jeong, Lou, Mailliard, Maio, Okafo, Osswald, Pasquier, Polak, Pradel, de Rooij, Schaeffer, Skeberdis, Smith, Tanveer, Volkmann, Wu and Zurzolo
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SubjectTerms	Age Alzheimer Biology Cancer Cell interactions Cell signaling Chemokines Communication Communications systems Cytokines Dendritic cells Disease Electrical stimuli Exosomes Gap junctions Growth factors Infections inflammation Laboratories Life Sciences Medical research Nanotubes Neuroscience Neurosciences Neurotransmitters Oncology Organelles Pediatrics reactivation Social research
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Title	Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions
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