Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A

• Published in: BMC medical genetics Vol. 17; no. 1; p. 80
• Main Authors: Cadzow, Murray, Merriman, Tony R., Boocock, James, Dalbeth, Nicola, Stamp, Lisa K., Black, Michael A., Visscher, Peter M., Wilcox, Phillip L.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.11.2016; BioMed Central
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Analysis; Body Mass Index; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Evolution; Female; Gene therapy; Genetic aspects; Genomes; Genotype; Gout - genetics; Gout - pathology; Haplotypes; Humans; Hypotheses; Insulin resistance; Linear Models; Logistic Models; Male; Middle Aged; Natural selection; Obesity; Odds Ratio; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics; Polymorphism, Single Nucleotide; Rheumatism; Risk factors; Samoa; Selection, Genetic; Tonga; Type 2 diabetes; White people; Young Adult; Samoa; Tonga; New Zealand; Cook Islands; Type 2 diabetes; Thrifty gene; Gout; BMI; Natural selection; Selective sweeps

The gene PPARGC1A, in particular the Gly482Ser variant (rs8192678), had been proposed to be subject to natural selection, particularly in recent progenitors of extant Polynesian populations. Reasons include high levels of population differentiation and increased frequencies of the derived type 2 dia...