Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1A - Cadzow, Murray; Merriman, Tony R.; Boocock, James; Dalbeth, Nicola; Stamp, Lisa K.; Black, Michael A.; Visscher, Peter M.; Wilcox, Phillip L. (BMC medical genetics, 2016)
Keywords: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Analysis; Body Mass Index; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Evolution; Female; Gene therapy; Genetic aspects; Genomes; Genotype; Gout - genetics; Gout - pathology; Haplotypes; Humans; Hypotheses; Insulin resistance; Linear Models; Logistic Models; Male; Middle Aged; Natural selection; Obesity; Odds Ratio; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics; Polymorphism, Single Nucleotide; Rheumatism; Risk factors; Samoa; Selection, Genetic; Tonga; Type 2 diabetes; White people; Young Adult; Samoa; Tonga; New Zealand; Cook Islands; Type 2 diabetes; Thrifty gene; Gout; BMI; Natural selection; Selective sweeps