PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?

• Published in: Frontiers in oncology Vol. 12; p. 819128
• Main Authors: Peng, Yan, Wang, Yuanyuan, Zhou, Cheng, Mei, Wuxuan, Zeng, Changchun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.03.2022
• Subjects: cancer; oncogenic alterations; Oncology; PI3K/Akt/mTOR pathway; precision medicine; targeted therapy; oncogenic alterations; targeted therapy; precision medicine; cancer; PI3K/Akt/mTOR pathway

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also an impediment to improving life expectancy worldwide. Furthermore, the global burden of cancer incidence and death is continuously growing. Current therapeutic options are insufficient for patients, and...