Adipose tissue gene expression of CXCL10 and CXCL11 modulates inflammatory markers in obesity: implications for metabolic inflammation and insulin resistance

• Published in: Therapeutic advances in endocrinology and metabolism Vol. 11; p. 2042018820930902
• Main Authors: Kochumon, Shihab, Madhoun, Ashraf Al, Al-Rashed, Fatema, Azim, Rafaat, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 2020; Sage Publications Ltd; SAGE Publishing
• Subjects: Adipose tissue; Biomarkers; Blood glucose; Body mass; Body mass index; Body size; Body weight; C-reactive protein; CCL18 protein; CCL19 protein; Chemokines; Correlation; CXCL10 protein; CXCL11 protein; Enzyme-linked immunosorbent assay; Gene expression; Inflammatory diseases; Infrared analysis; Insulin; Insulin resistance; Interleukin 6; Multiple regression analysis; NF-κB protein; Obesity; Original Research; Overweight; Polymerase chain reaction; Ribonucleic acid; RNA; RNA-directed DNA polymerase; TLR3 protein; TLR4 protein; Toll-like receptors; CXCL10; CXCL9; CXCL11; adipose tissue; insulin resistance; metabolic inflammation; obesity

Background: The CXCL subfamily of chemokines (CXCL9, CXCL10, and CXCL11; angiostatic chemokines) plays a key role in many inflammatory diseases. However, the expression of CXCLs in adipose tissue (AT) during obesity and association of these CXCLs with inflammatory markers and insulin resistance are...