Adrenal Aging and Its Implications on Stress Responsiveness in Humans

• Published in: Frontiers in endocrinology (Lausanne) Vol. 10; p. 54
• Main Authors: Yiallouris, Andreas, Tsioutis, Constantinos, Agapidaki, Eirini, Zafeiri, Maria, Agouridis, Aris P., Ntourakis, Dimitrios, Johnson, Elizabeth O.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.02.2019
• Subjects: adrenal cortex; Endocrinology; glucocorticoids; HPA axis; senescence; stress; senescence; stress; HPA axis; glucocorticoids; adrenal cortex

Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy alteration in the normal circadian rhythm pattern. Glucocorticoid excess seen in the elderly population can have s...