The Discovery and Development of Liraglutide and Semaglutide

• Published in: Frontiers in endocrinology (Lausanne) Vol. 10; p. 155
• Main Authors: Knudsen, Lotte Bjerre, Lau, Jesper
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.04.2019
• Subjects: albumin; Endocrinology; GLP-1; liraglutide; obesity; semaglutide; type 2 diabetes; liraglutide; once-weekly; GLP-1; type 2 diabetes; albumin; obesity; semaglutide

The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects on glycemic control and body weight regulation, led to efforts to extend its half-life and make it therapeutically effective in people with type 2 diabetes (T2D). The development of short- and then long-acti...