Photodynamic Therapy for the Treatment of Glioblastoma
Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is near...
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| Published in | Frontiers in surgery Vol. 6; p. 81 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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21.01.2020
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| Abstract | Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Notably, >80% of recurrence is found in the region adjacent to the resection cavity. The need for improved local control in this region, thus remains unmet. The FDA approval of 5-aminolevulinic acid (5-ALA) for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT). Here we review the general principles of PDT as well as the available literature on PDT as a glioblastoma therapeutic platform. |
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| AbstractList | Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Notably, >80% of recurrence is found in the region adjacent to the resection cavity. The need for improved local control in this region, thus remains unmet. The FDA approval of 5-aminolevulinic acid (5-ALA) for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT). Here we review the general principles of PDT as well as the available literature on PDT as a glioblastoma therapeutic platform.Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Notably, >80% of recurrence is found in the region adjacent to the resection cavity. The need for improved local control in this region, thus remains unmet. The FDA approval of 5-aminolevulinic acid (5-ALA) for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT). Here we review the general principles of PDT as well as the available literature on PDT as a glioblastoma therapeutic platform. Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the chemotherapy temozolomide. Recurrence after this therapy is nearly universal within 2 years of diagnosis. Notably, >80% of recurrence is found in the region adjacent to the resection cavity. The need for improved local control in this region, thus remains unmet. The FDA approval of 5-aminolevulinic acid (5-ALA) for fluorescence guided glioblastoma resection renewed interests in leveraging this agent as a means to administer photodynamic therapy (PDT). Here we review the general principles of PDT as well as the available literature on PDT as a glioblastoma therapeutic platform. |
| Author | Chen, Clark C. Cramer, Samuel W. |
| AuthorAffiliation | Department of Neurosurgery, University of Minnesota , Minneapolis, MN , United States |
| AuthorAffiliation_xml | – name: Department of Neurosurgery, University of Minnesota , Minneapolis, MN , United States |
| Author_xml | – sequence: 1 givenname: Samuel W. surname: Cramer fullname: Cramer, Samuel W. – sequence: 2 givenname: Clark C. surname: Chen fullname: Chen, Clark C. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32039232$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2020 Cramer and Chen. Copyright © 2020 Cramer and Chen. 2020 Cramer and Chen |
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| Keywords | glioblastoma multiforme (GBM) brain tumor photodynamic therapy (PDT) neurosurgery tumor-targeting |
| Language | English |
| License | Copyright © 2020 Cramer and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Konstantin Slavin, University of Illinois at Chicago, United States; Mario Ganau, University of Trieste, Italy Edited by: Eberval Figueiredo, University of São Paulo, Brazil This article was submitted to Neurosurgery, a section of the journal Frontiers in Surgery |
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