The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases

• Published in: Frontiers in pharmacology Vol. 7; p. 23
• Main Authors: Vukićević, Tanja, Schulz, Maike, Faust, Dörte, Klussmann, Enno
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.02.2016
• Subjects: AKAP; AVP; cAMP; Heart Failure; Pharmacology; PKA; SIADH; heart failure; NDI; AKAP; PKA; AVP; AQP2; SIADH; cAMP

Arginine-vasopressin (AVP) stimulates the redistribution of water channels, aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. By this AVP directs 10% of the water reabsorption from the 170 L of primary urine that the human kidneys produ...