The evolution of the GALactose utilization pathway in budding yeasts

• Published in: Trends in genetics Vol. 38; no. 1; pp. 97 - 106
• Main Authors: Harrison, Marie-Claire, LaBella, Abigail L., Hittinger, Chris Todd, Rokas, Antonis
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2022; Elsevier
• Subjects: BASIC BIOLOGICAL SCIENCES; fungi; Galactose; Galactose - genetics; Galactose - metabolism; gene cluster; gene regulation; Genes, Fungal; horizontal gene transfer; Humans; Multigene Family; polymorphism; regulatory rewiring; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomycetales - genetics; Saccharomycetales - metabolism; gene regulation; fungi; regulatory rewiring; galactose; polymorphism; gene cluster; horizontal gene transfer

The Leloir galactose utilization or GAL pathway of budding yeasts, including that of the baker’s yeast Saccharomyces cerevisiae and the opportunistic human pathogen Candida albicans, breaks down the sugar galactose for energy and biomass production. The GAL pathway has long served as a model system...