Long-term intermittent low-frequency repetitive transcranial magnetic stimulation effectively controls seizures in two drug-free adolescent patients

• Published in: Journal of international medical research Vol. 47; no. 8; pp. 3968 - 3971
• Main Authors: Li, Hongzhan, Wang, Chunyan, Zhang, Shaotian, Zhang, Chengliang, Lu, Rulan, Yun, Wenwei, Zhou, Xianju
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2019; Sage Publications Ltd; SAGE Publishing
• Subjects: Adolescent; Adult; Case Report and Case Series; Convulsions & seizures; Epilepsy; Female; Humans; Male; Seizures - therapy; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods; Treatment Outcome; Young Adult; convulsion; seizure; cortical dysplasia; Epilepsy; adolescent; low frequency; repetitive transcranial magnetic stimulation
• ISSN: 0300-0605; 1473-2300; 1473-2300
• DOI: 10.1177/0300060519862950

Recently, repetitive transcranial magnetic stimulation (rTMS) has been widely used for treating neurological and psychiatric diseases. Low-frequency rTMS is used to effectively control the occurrence of seizures, including medication-refractory epilepsy and cortical dysplasia or neocortical epilepsy. However, there have been no reports on the effects of long-term rTMS on epilepsy. We observed the clinical effects of long-term rTMS in two drug-free adolescent epileptic patients with a preference for non-drug therapy. The two drug-free adolescent patients, who underwent intermittent low-frequency rTMS treatment for 36 weeks, obtained effective control of seizures (including episode and severity). However, a systematic study is required to confirm our observations.